Results 121 to 130 of about 10,105,993 (275)

Generalized empirical likelihood estimators and tests under partial, weak and strong identification [PDF]

The principal purpose of this paper is to describe the performance of generalized empirical likelihood (GEL) methods for time series instrumental variable models specified by nonlinear moment restrictions when identification may be weak.
Patrik Buggenberger, Richard Smith
core  

An unconditional maximum likelihood test for a unit root [PDF]

, 1993
We investigate a test for unit roots in autoregressive time series based on maximization of the unconditional likelihood. This is the likelihood function appropriate for stationary time series.
González-Farias, Graciela, Dickey, David A.   +1 more
core   +1 more source

Evaluation of Seed Yield Stability of Lentil Genotypes by Linear Mixed‐Effects Models and Multitrait Stability Index

Legume Science
To evaluate performance stability for 13 lentil genotypes, experiments were performed at three locations, Ardebil, Zanjan, and Maragheh, during three growing seasons (2011–2013).
Seyedeh Soudabeh Shobeiri, Payam Pezeshkpour, Bita Naseri   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A generalized likelihood ratio test for monitoring profile data. [PDF]

J Appl Stat, 2021
Liu Y, Zhu J, Lin DKJ.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Lack-of-fit tests in semiparametric mixed models. [PDF]

In this paper we obtain the asymptotic distribution of restricted likelihood ratio tests in mixed linear models with a fixed and finite number of random effects.
Claeskens, Gerda, Ding, Huijuan, Jansen, Maarten   +2 more
core  

Likelihood ratio test for genetic association study with case-control data under Probit model. [PDF]

J Appl Stat, 2022
Sheng Z, Liu Y, Li P, Qin J.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Joint Tests for Zero Restrictions on Non-negative Regression Coefficients [PDF]

Three tests for zero restrictions on regression coefficients that are known to be nonnegative are considered: the classical F test, the likelihood ratio test, and a one-sided t test in a particular direction. Critical values for the likelihood ratio test
Hillier, Grant
core