Results 101 to 110 of about 10,105,993 (275)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Reduce computation in profile empirical likelihood method [PDF]
Since its introduction by Owen in [29, 30], the empirical likelihood method has been extensively investigated and widely used to construct confidence regions and to test hypotheses in the literature.
Peng, Liang, Li, Minqiang, Qi, Yongcheng
core
Testing for zero-modification in count regression models [PDF]
, 2006 Count data often exhibit overdispersion and/or require an adjustment for zero outcomes with respect to a Poisson model. Zero-modified Poisson (ZMP) and zero-modified generalized Poisson (ZMGP) regression models are useful classes of models for such ...
Min, Aleksey, Czado, Claudia
core +1 more source
Making sense of diagnostic tests likelihood ratios
Evidence-Based Medicine, 2006 A smart mother makes often a better diagnosis than a poor doctor. August Bier German, professor of surgery 1861–1949. Statistical diagnosis is a mystery to many health practitioners.1 Information is often presented as test accuracy (sensitivity and specificity).
Perera, R, Heneghan, C
openaire +4 more sources
Weak Change Detection: A Review
MathematicsThis article provides a selective review of offline change-point detection methods, with a particular emphasis on weak change-points. The study of such weak changes plays a central role in establishing the asymptotic properties of test statistics ...
Fatma Aouissaoui, Joseph Ngatchou-Wandji
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
"Empirical Likelihood-Based Inference in Conditional Moment Restriction Models" [PDF]
This paper proposes an asymptotically efficient method for estimating models with conditional moment restrictions. Our estimator generalizes the maximum empirical likelihood estimator (MELE) of Qin and Lawless (1994).
Hyungtaik Ahn +2 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source