Results 101 to 110 of about 643,997 (233)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Likelihood ratio test for genetic association study with case-control data under Probit model. [PDF]
J Appl Stat, 2022 Sheng Z, Liu Y, Li P, Qin J.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
On the Likelihood Ratio Test of a Normal Multivariate Testing Problem II
The Annals of Mathematical Statistics, 1964 Let the random vector $X = (X_1 \cdots X_p)'$ have a multivariate normal distribution with unknown mean $\xi = (\xi_1 \cdots \xi_p)'$ and unknown nonsingular covariance matrix $\Sigma$. Write $\Sigma^{-1}\xi = \Gamma = (\Gamma_1 \cdots \Gamma_p)'$. The problem considered here is that of testing the hypothesis $H_0 : \Gamma_{q + 1} = \cdots = \Gamma_p =
openaire +4 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Real-Time Detection of Incipient Inter-Turn Short Circuit and Sensor Faults in Permanent Magnet Synchronous Motor Drives Based on Generalized Likelihood Ratio Test and Structural Analysis. [PDF]
Sensors (Basel), 2022 Hasan Ebrahimi S, Choux M, Huynh VK.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Novel Decoder for Unknown Diversity Channels Employing Space-Time Codes
EURASIP Journal on Advances in Signal Processing, 2002 We suggest new decoding techniques for diversity channels employing space time codes (STC) when the channel coefficients are unknown to both transmitter and receiver.
Erez Elona, Feder Meir
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source