Results 91 to 100 of about 643,997 (233)

Likelihood-ratio test statistic for the finite-sample case in nonlinear ordinary differential equation models. [PDF]

PLoS Comput Biol, 2023
Tönsing C, Steiert B, Timmer J, Kreutz C.   +3 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Evaluation of Seed Yield Stability of Lentil Genotypes by Linear Mixed‐Effects Models and Multitrait Stability Index

Legume Science
To evaluate performance stability for 13 lentil genotypes, experiments were performed at three locations, Ardebil, Zanjan, and Maragheh, during three growing seasons (2011–2013).
Seyedeh Soudabeh Shobeiri, Payam Pezeshkpour, Bita Naseri   +2 more
doaj   +1 more source

Generalized Likelihood Ratio Test for Hyperspectral Subpixel Target Detection Based on Segmented Mixing Model

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
For hyperspectral subpixel target detection tasks, conventional mixing model (CMM) is one of the most intensively used models. Despite the flexibility of CMM in terms of mixing coefficient, it is sometimes inappropriate to assume that all bands share the
Yubo Ma, Jie Zhou, Siyu Cai, Qingke Zou
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The asymptotic distribution of the likelihood ratio test statistic in two-peak discovery experiments

European Physical Journal C: Particles and Fields
Likelihood ratio tests are widely used in high-energy physics, where the test statistic is usually assumed to follow a chi-squared distribution with a number of degrees of freedom specified by Wilks’ theorem.
Clara Bertinelli Salucci, Hedvig Borgen Reiersrud, A. L. Read, Anders Kvellestad, Riccardo De Bin   +4 more
doaj   +1 more source

A generalized likelihood ratio test for monitoring profile data. [PDF]

J Appl Stat, 2021
Liu Y, Zhu J, Lin DKJ.
europepmc   +1 more source