Results 71 to 80 of about 643,997 (233)

Garch Model Test Using High-Frequency Data

Mathematics, 2020
This work is devoted to the study of the parameter test for the Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model. Based on the daily GARCH model, using the parameter estimator obtained by intraday high-frequency data, the adjusted ...
Chunliang Deng, Xingfa Zhang, Yuan Li, Qiang Xiong   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Likelihood-Ratio and Confidence-Region Tests

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1965
Summary A previous paper (Aitchison, 1964) proposed a method of confidence-region testing for multiple-hypothesis situations and developed the theory for linear univariate situations and for the asymptotic parametric case. The present paper shows that the results for these situations are in fact special cases of a basic relation between ...
openaire   +2 more sources

Bayesian and Frequentist Bartlett Corrections for Likelihood Ratio and Conditional Likelihood Ratio Tests

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1992
SUMMARY This paper characterizes priors under which the Bayesian and frequentist Bartlett corrections for the likelihood ratio and the conditional likelihood ratio (CLR) statistics differ by o(1). It is seen that, except for sample points with negligible probability, the CLR statistic has a posterior distribution for which a posterior ...
Ghosh, J. K., Mukerjee, Rahul
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An Augmented Generalized Likelihood Ratio Test Detector for Signal Detection in Clutter and Noise

IEEE Access, 2019
To deal with the problem of signal detection in correlated subspace, this paper presents an augmented generalized likelihood ratio test (AGLRT) detector.
Hui Tang, Li Chai, Xianrong Wan
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Novel Ship Detector Based on the Generalized-Likelihood Ratio Test for SAR Imagery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2017
Ship detection with synthetic aperture radar (SAR) images, acquired at different working frequencies, is presented in this paper where a novel technique is proposed based on the generalized-likelihood ratio test (GLRT).
Pasquale Iervolino, Raffaella Guida
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source