Results 71 to 80 of about 10,105,993 (275)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Non-invasive screening: The probability of events [PDF]
Archives of Biological Sciences, 2011 Congenital anomalies are the cause of 20.0-25.0% of cases of perinatal death, while 3.0% of children are born with malformations of varying size.
Lončar D. +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A likelihood ratio test for mixture effects [PDF]
Behavior Research Methods, 2006 Under certain circumstances, it is theoretically important to decide whether a difference between two conditions in mean reaction time (RT) results from a relatively uniform slowing of all the responses in the slower condition or from a mixture of some slowed trials with some unslowed ones.
openaire +2 more sources
Journal of Probability and Statistics, 2021 An omnibus test for normality with an adjustment for symmetric alternatives is developed using the empirical likelihood ratio technique. We first transform the raw data via a jackknife transformation technique by deleting one observation at a time.
Chioneso Show Marange, Yongsong Qin
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Likelihood Ratio Tests for Monotone Functions
The Annals of Statistics, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Banerjee, Moulinath, Wellner, Jon A.
openaire +2 more sources
A Likelihood-Ratio Test of Monophyly [PDF]
Systematic Biology, 1996 Many phylogenetic analyses are inspired by or depend upon the monophyly of a group specified a priori. Also, many evolutionary problems for which phytogenies are useful do not require every detail of the phylogeny to be estimated correctly but depend upon the monophyly (or lack thereof) of a particular group.
John P. Huelsenbeck +2 more
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Testing for the Monotone Likelihood Ratio Assumption [PDF]
Monotonicity of the likelihood ratio for conditioned densities is a common technical assumption in economic models. But we have found no empirical tests for its plausibility.
Hennessy, David A., Roosen, Jutta
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