Results 131 to 140 of about 33,726 (347)

Limb Reconstruction and Lengthening

, 2021
Christopher Iobst, Sarah Wiskerchen, Ryan D. Muchow   +2 more
openalex   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Transfemoral Osseointegration for Amputees with Well-Managed Diabetes Mellitus

JBJS Open Access
Background:. The most common reason for lower-extremity amputations remains the management of complications of diabetes mellitus (DM) and/or peripheral vascular disease.
Jason S. Hoellwarth, MD, Shakib Al-Jawazneh, MD, Atiya Oomatia, BEng(Biomed), Kevin Tetsworth, MD, FRACS, Munjed Al Muderis, MBChB   +4 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A comparison of the complications and effectiveness of intramedullary limb lengthening [PDF]

, 2020
Fuhuan Chen
openalex   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

An assessment of the inter-rater and intra-rater reliability of the modified Gordon pin infection classification system

Digital Health
Objectives A grading system deployed for continuous at-home monitoring of pin sites would potentially increase the chances of early detection of pin-site infections and the commencement of early treatment. The first five grades of the Modified Gordon Pin
Anirejuoritse Bafor, Regitze Gyldenholm Skals, Ming Shen, Christopher A Iobst, Ole Rahbek, Søren Kold, Marie Fridberg   +6 more
doaj   +1 more source

Local Antibiotic Delivery Systems and Their Applications in Orthopaedic Surgery

JBJS Open Access
. » Local antibiotic delivery systems are critical in managing periprosthetic and fracture-related infections, providing high local antibiotic concentrations without systemic side effects.
Amir Human Hoveidaei, MD, MSc, Amirhosein Sabaghian, Erfan Basirat, MD, Akam Ramezani, MD, Henry Tout Shu, MD, Janet D. Conway, MD, FAAOS   +5 more
doaj   +1 more source

Aging and Muscle Fatigability in the Upper Extremity [PDF]

, 2017
Aging is accompanied by reductions in strength and contraction velocity, and increased fatigability of limb muscles during high-velocity dynamic contractions.
Kuplic, Andrew
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source