Results 111 to 120 of about 308,349 (254)

Lengthening for functional acetabular dysplasia due to limb length discrepancy: A report of two cases

, 2016
Osteoarthritis of the hip joint as a complication of limb length discrepancy (LLD) caused by lower extremity deformity is rarely reported in the literature.
Munetomo Takata, Hidenori Matsubara, Yasuhisa Yoshida, Shogo Shimbashi, Shuhei Ugaji, Hiroyuki Tsuchiya, Takao Aikawa   +6 more
core   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

An assessment of the inter-rater and intra-rater reliability of the modified Gordon pin infection classification system

Digital Health
Objectives A grading system deployed for continuous at-home monitoring of pin sites would potentially increase the chances of early detection of pin-site infections and the commencement of early treatment. The first five grades of the Modified Gordon Pin
Anirejuoritse Bafor, Regitze Gyldenholm Skals, Ming Shen, Christopher A Iobst, Ole Rahbek, Søren Kold, Marie Fridberg   +6 more
doaj   +1 more source

Assessing Psychological Contributions to the Outcome of Limb Lengthening

, 2016
In the process of limb lengthening and deformity correction, the bone lengthens or is realigned at a rate up to 1 mm per day, which is much faster than a bone would grow naturally.
Nicholl, Meg, Smith, Evan, Serpa, Sophia, Nierenberg, Barry, Tabio, Laura, Mayersohn, Gillian   +5 more
core  

Health-related Quality of Life in Patients with Achondroplasia after Global Limb-lengthening Surgery: A Case Series

Background: Achondroplasia can impact daily activities and impair quality of life (QoL). Surgical lengthening of the upper and lower limbs has been reported to increase independence and improve QoL, but further evidence is needed to allow well-informed ...
Carolina Echavarria, Nicole Canu, Joana Lebre, Maximiliano Ibáñez, Miriam Pérez, Ignacio Ginebreda   +5 more
core   +1 more source

Limb lengthening and deformity correction in children with abnormal bone.

, 2019
Flexible intramedullary nailing (FIN) provides multiple advantages in limb lengthening and progressive deformity correction in combination with external fixation. The article presents brief literature review and authors' experience in limb lengthening of
Lazović M, Popkov A, Dučić S, Popkov D, Lascombes P   +4 more
core   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Local Antibiotic Delivery Systems and Their Applications in Orthopaedic Surgery

JBJS Open Access
. » Local antibiotic delivery systems are critical in managing periprosthetic and fracture-related infections, providing high local antibiotic concentrations without systemic side effects.
Amir Human Hoveidaei, MD, MSc, Amirhosein Sabaghian, Erfan Basirat, MD, Akam Ramezani, MD, Henry Tout Shu, MD, Janet D. Conway, MD, FAAOS   +5 more
doaj   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source