Results 121 to 130 of about 409,963 (250)

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Total talar replacement as a salvage procedure for multiple recurrent osteoblastoma: A case report

Foot & Ankle Surgery: Techniques, Reports & Cases
Background: Osteoblastoma is a rare benign bone tumor with potential local aggressiveness. Treating multiple recurrent osteoblastomas is challenging because of their high recurrence rates.
Hironari Tamiya, Haruna Takami, Yuji Kato, Ken-ichi Yoshida, Rie Suzuki, Toru Wakamatsu, Shigeki Kakunaga, Satoshi Takenaka, Outani Hidetatsu, Seiji Okada   +9 more
doaj   +1 more source

Functional and oncological outcomes after limb-salvage surgery for primary sarcomas of the upper limb.

, 2016
The surgical treatment of upper limb sarcoma poses an oncological and reconstructive challenge. Limb-salvage surgery aims to balance adequate excision margins for disease control and preservation of all important structures to retain maximum function ...

core   +1 more source

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

National Materials, EarlyView.
In this study, we engineered an antibacterial, antioxidative and epidermal grow factor‐encapsulated multifunctional hydrogel for the repair of chronic and refractory wounds. The hydrogel markedly promoted wound healing in rat models of diabetic foot ulcers and infected wounds by modulating wound microenvironment.
Zheng Zou, Yang Gao, Desheng Qi, Zhen Zhang, Chaoliang He, Xuesi Chen   +5 more
wiley   +1 more source

Treatment and results in 29 patients with distal tibia osteosarcoma treated with limb salvage surgery

, 2012
Treatment and results in 29 patients with distal tibia osteosarcoma treated with limb salvage ...
ABATI C. N, CHEONG D, RUGGIERI, PIETRO, MAVROGENIS A. F, PALA, ELISA, LETSON D.   +5 more
core   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Amputation in patients with extremity soft tissue sarcoma: the experience of an East Asian referral center

BMC Cancer
Background This study aimed to investigate the characteristics and clinical outcomes in a series of patients with extremity soft tissue sarcoma (STS) who underwent amputation at a large East Asian referral center. Patients and methods Of the 652 patients
Yongsung Kim, Han-Soo Kim, Ilkyu Han
doaj   +1 more source

Biomimetic PB@PDA‐CA@Mem nanoplatform regulates oxidative stress and inflammatory microenvironment to enhance stroke recovery

VIEW, EarlyView.
PB@PDA‐CA@Mem enhances ischemic brain accumulation and enables acid‐responsive CA release. Through broad‐spectrum ROS/RNS scavenging, Nrf2/Keap1 activation, and NF‐κB/NLRP3 suppression, it alleviates oxidative stress and neuroinflammation, preserves neuronal architecture, reduces infarction, and improves functional recovery.
Lei Shi, Zhuonan Wang, Chenxi Zhou, Shuping Wang, Xuting Shen, Si Cheng, Yongli Yang, Nengrui Guo, Zhengrong Zhong, Lijun Bai   +9 more
wiley   +1 more source

The Fibula Free Flap as Used for Reconstruction in Patients With Oral Cavity Malignancy: A Systematic Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The fibula free flap is a widely used means of reconstructing the maxilla and mandible. It is used for a variety of indications, including for reconstruction after resection of a benign or malignant tumor, osteoradionecrosis, or trauma.
Rohan Vuppala, Nicholas Owings, Forest Weir   +2 more
wiley   +1 more source