Results 71 to 80 of about 6,717 (307)

Limb salvage surgery for pathological fractures in osteosarcoma [PDF]

International Orthopaedics, 2000
The local treatment of pathological fracture in patients with a primary osteosarcoma remains controversial. In this paper we report the oncological outcome of the treatment of pathological fractures in 18 patients suffering from this disease. There were ten male and eight female patients, and the average age at diagnosis was 17 years.
M V, Natarajan, R H, Govardhan, S, Williams, T S, Raja Gopal   +3 more
openaire   +2 more sources

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Limb salvage in bone sarcomas in patients younger than age 10. A 20-year experience. [PDF]

, 2003
The authors present their experience over the last 20 years in limb salvage procedures of a consecutive series of 40 children under 10 years of age (range 2-10 years) with bone sarcomas. Nineteen were osteogenic sarcomas and 21 were Ewing sarcomas.
Cañadell, J.M. (J. M.), Dolz, R. (Rodrigo), Garcia-Barrecheguren, E. (E.), Noain, E. (E.), San-Julian, M. (Mikel), Sierrasesumaga, L. (Luis)   +5 more
core  

Resorbable Mesh Cranioplasty Repair of Bilateral Cerebrospinal Fluid Leaks Following Pediatric Simultaneous Bilateral Auditory Brainstem Implant Surgery [PDF]

, 2017
OBJECTIVE: To present a child with cochlear nerve deficiency (CND) who received simultaneous bilateral simultaneous auditory brainstem implants (BS-ABI) and subsequently presented with bilateral cerebrospinal fluid (CSF) leaks unresponsive to standard ...
Allevi Fabiana, Colletti Giacomo, Colletti Liliana, Colletti Vittorio, Deganello Alberto, Mandalà Marco   +5 more
core   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Limb Salvage and Reconstruction of a Complex Upper Extremity Injury: A Case Report

Journal of Orthopaedic Case Reports
Introduction: Complex upper extremity trauma poses us with significant challenges in orthopedic and reconstructive surgery due to the complex anatomy and functional importance of the extremities.
Christos Koukos, Mikail Chatzivasiliadis, Stylianos Kapetanakis, David Latz, S Samundeeswari, Fredy Montoya   +5 more
doaj   +1 more source

Outcome of expandable endoprosthesis: A single centre retrospective review

Journal of Orthopaedic Surgery, 2019
Purpose: Expandable endoprosthesis allows limb salvage in children with an option to leading a better life. However, the revision rate and implant-related complications impose as a limitation in the skeletal immature.
Vivek Ajit Singh, Dinesh Earnest Kunasingh, Amber Haseeb, Nor Faissal Yasin   +3 more
doaj   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Advancing pediatric bone sarcoma care: navigating complications and innovating solutions in limb salvage and reconstruction–why, when, and how to treat limb length inequalities

Acta Orthopaedica et Traumatologica Turcica
Pediatric bone sarcomas, particularly osteosarcomas, present unique challenges in the realm of orthopedic oncology, given their predilection for the metaphyseal regions of long bones and the intricate balance required between achieving oncologic control ...
Levent Eralp, S. Robert Rozbruch, Melih Civan   +2 more
doaj   +1 more source

Impact of high prevalence of pseudomonas and polymicrobial gram-negative infections in major sub-/total traumatic amputations on empiric antimicrobial therapy: a retrospective study [PDF]

, 2014
INTRODUCTION: Emergency treatment of major sub-/total traumatic amputations continue to represent a clinical challenge due to high infection rates and serious handicaps.
Andrej Trampuz, Christian Kleber, Florian Wichlas, Moritz T Giesecke, Philipp Schwabe   +4 more
core   +1 more source