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Paraneoplastic Limbic Encephalitis
Psychosomatics, 2009Paraneoplastic limbic encephalitis (PLE) is a syndrome characterized by the development of neuropsychiatric symptoms due to a misdirected tumor-activated antibody response that damages host neural tissue. Definitive treatment relies on the identification and ablation of the underlying tumor.
Alison R, Foster, Jason P, Caplan
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Autoimmune limbic encephalitis
Acta Neurologica Scandinavica, 2009Autoimmune limbic encephalitis (LE) can arise both by paraneoplastic and non-paraneoplastic mechanisms. Patients with LE usually have a subacute onset of memory impairment, disorientation and agitation, but can also develop seizures, hallucinations and sleep disturbance.
C A, Vedeler, A, Storstein
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Neurology, 2008
Limbic encephalitis (LE) was initially described as a paraneoplastic syndrome characterized by rapid development of confusion, seizures, short-term memory loss, and high MRI T2 and FLAIR signal involving one or both medial temporal lobes.1 No more than 5 years ago, LE was considered to invariably have a paraneoplastic origin mostly associated with lung
Francesc Graus, Albert Saiz
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Limbic encephalitis (LE) was initially described as a paraneoplastic syndrome characterized by rapid development of confusion, seizures, short-term memory loss, and high MRI T2 and FLAIR signal involving one or both medial temporal lobes.1 No more than 5 years ago, LE was considered to invariably have a paraneoplastic origin mostly associated with lung
Francesc Graus, Albert Saiz
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CD8+ T‐Lymphocyte–Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy
Annals of Neurology, 2020Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected brain structures including the presence of autoantibodies and lymphoid cells.
J. Pitsch +17 more
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Limbic encephalitis and psychosis
General Hospital Psychiatry, 2013To report a case of limbic encephalitis (LE) presenting with psychosis.Case report.A woman with LE initially presented with acute psychotic symptoms. Magnetic resonance imaging (MRI) showed hyperintensity in bilateral temporal lobes. Paraneoplastic and autoimmune antibodies were negative, but symptoms resolved after starting methylprednisolone.A ...
Kairav, Shah +5 more
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Limbic encephalitis – a review
Journal of Clinical Neuroscience, 2008The clinical features of limbic encephalitis are diverse and early diagnosis of the disorder is frequently difficult. Four patients with limbic encephalitis are described. An antineuronal antibody was identified in three of these patients. Antibodies directed against voltage-gated potassium channels, the N-methyl-D-aspartate receptor and an ...
N E, Anderson, P A, Barber
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Diagnosis and treatment of limbic encephalitis in the cancer patient.
Future Oncology, 2020Limbic encephalitis is an inflammatory process involving the limbic structures of the brain, manifested with short-term memory deficits, confusion, depression and seizures.
A. Kyritsis +6 more
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Metabolic Imaging Patterns on 18F-FDG PET in Acute and Subacute LGI1 Autoimmune Limbic Encephalitis.
Clinical Nuclear Medicine, 2020Autoimmune encephalitis is a diverse group of neuropsychiatric disorders, which are difficult to diagnose clinically. The disorder presents acutely or subacutely with alteration of consciousness, cognitive decline, seizures, and abnormal movements ...
Nikhil Seniaray +4 more
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Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies
Journal of Neurology, 2022D. Guery +10 more
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Three cases of antibody-LGI1 limbic encephalitis and review of literature
International Journal of Neuroscience, 2019Purpose: Antibody-LGI1 limbic encephalitis (LGI1-Ab LE) is an anti-neuronal surface antigen-related autoimmune encephalitis. we report three cases of LGI1-Ab LE, describe the characteristics of clinical manifestation, course of evolution, imaging ...
Bingqian Wang +6 more
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