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2022
Limbic encephalitis (LE) is a clinical syndrome defined by subacutely evolving limbic signs and symptoms with structural and functional evidence of mediotemporal damage in the absence of a better explanation than an autoimmune (or paraneoplastic) cause. There are features common to all forms of LE.
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Limbic encephalitis (LE) is a clinical syndrome defined by subacutely evolving limbic signs and symptoms with structural and functional evidence of mediotemporal damage in the absence of a better explanation than an autoimmune (or paraneoplastic) cause. There are features common to all forms of LE.
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Limbic encephalitis and psychosis
General Hospital Psychiatry, 2013To report a case of limbic encephalitis (LE) presenting with psychosis.Case report.A woman with LE initially presented with acute psychotic symptoms. Magnetic resonance imaging (MRI) showed hyperintensity in bilateral temporal lobes. Paraneoplastic and autoimmune antibodies were negative, but symptoms resolved after starting methylprednisolone.A ...
Paula Tabares +5 more
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Paraneoplastic Limbic Encephalitis
Psychosomatics, 2009Paraneoplastic limbic encephalitis (PLE) is a syndrome characterized by the development of neuropsychiatric symptoms due to a misdirected tumor-activated antibody response that damages host neural tissue. Definitive treatment relies on the identification and ablation of the underlying tumor.
Alison R. Foster +3 more
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Autoimmune limbic encephalitis
Acta Neurologica Scandinavica, 2009Autoimmune limbic encephalitis (LE) can arise both by paraneoplastic and non-paraneoplastic mechanisms. Patients with LE usually have a subacute onset of memory impairment, disorientation and agitation, but can also develop seizures, hallucinations and sleep disturbance.
Christian A. Vedeler, Anette Storstein
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Striatal hypermetabolism in limbic encephalitis [PDF]
Journal of Neurology, 2011 Striatal hypermetabolism on 18FDG-PET scan is a neuroradiological finding that has been described in association with autoimmune disorders such as Sydenham chorea, lupus or antiphospholipid syndrome. Here, we report three patients with non-paraneoplastic limbic encephalitis characterized by 18FDG-PET hypermetabolism of both striata, in contrast with ...
Elsa Kaphan +6 more
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Limbic encephalitis – a review
Journal of Clinical Neuroscience, 2008The clinical features of limbic encephalitis are diverse and early diagnosis of the disorder is frequently difficult. Four patients with limbic encephalitis are described. An antineuronal antibody was identified in three of these patients. Antibodies directed against voltage-gated potassium channels, the N-methyl-D-aspartate receptor and an ...
Neil E Anderson, Peter Barber
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Neurosyphilis presenting as limbic encephalitis
BMJ Case Reports, 2023A man in his 50s presented with focal seizures and was found to have an inflammatory cerebrospinal fluid (CSF) with bilateral mesiotemporal lobe hyperintensity on magnetic resonance imaging (MRI) of the brain. Corticosteroid treatment was initiated for management of limbic encephalitis.
Matthew Shrimpton, Abhishek Malhotra
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Autoimmune Limbic Encephalitis
2019Autoimmune encephalitis is now being widely recognized as a common and potentially treatable cause of encephalitis. The majority of the autoimmune encephalitis cases clinically present with limbic system dysfunction. Many neural autoantibody biomarkers of autoimmune limbic encephalitis have been described, and novel antibodies are being recognized ...
Divyanshu Dubey +2 more
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Serial MRI of limbic encephalitis
Neuroradiology, 2006The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE.Serial MRI scans (1 day to 15 years after the onset of symptoms) of 20 patients with LE were retrospectively evaluated.
Monika Jeub +5 more
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