Results 131 to 140 of about 144,798 (322)

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source

经颅多普勒卧立位试验在脑血管病中的应用进展 Application Progress of the Recumbent-Upright Test Using Transcranial Doppler in Cerebrovascular Diseases

Zhongguo cuzhong zazhi
脑血流自动调节（cerebral autoregulation，CA）功能可维持正常脑血流灌注，对确保人正常生活及工作至关重要。CA障碍可发生在任何年龄段，在脑血管病或神经退行性疾病患者中尤为常见。TCD卧立位试验是一种运用TCD评估CA的无创、便捷方法，其关键在于监测患者从卧位到立位过程中脑血流速度和血管阻力的变化。TCD卧立位试验在脑血管病及自主神经功能障碍性疾病的诊断、治疗和预后评估方面具有重要临床应用价值，但标准化操作、结果解读和个体差异等挑战制约着其临床推广。未来，随着技术的进步和研究的深入 ...
王静祎1，2，李华1，2，曹黎明3，4 (WANG Jingyi1,2, LI Hua1,2, CAO Liming3,4 )
doaj   +1 more source

Effect of Nitric Oxide on Postharvest Quality of Lime Fruit (Citrus aurantifolia Swingle)

, 2016
et.al Amolsiri Nolpradubphan, Intira Lichanporn   +1 more
openalex   +1 more source

Sustainability Challenges to the Steel Industry in a Developing Country: Sanctions and Security Issues at the Forefront

Business Strategy and the Environment, EarlyView.
ABSTRACT This article contributes to sustainability research by investigating the complex, geopolitically induced challenges faced by industrial supply chains under international sanctions. Using Iran's steel industry as a case, it examines sustainability barriers through the lens of stakeholder theory. A mixed methods approach was employed.
Seyed Hamed Moosavirad, Mohammad Moshtari, Ali Esfahbodi   +2 more
wiley   +1 more source

Ammonia volatilization and nitrogen status in second-season corn after lime and gypsum application in no-till

, 2023
Evandro Antonio Minato, Marcos Renan Besen, Michel Esper Neto, Bruno Maia Abdo Rahmen Cassim, Éder Júnior de Oliveira Zampar, Tadeu Takeyoshi Inoue, Marcelo Augusto Batista   +6 more
openalex   +1 more source

Arene Incorporation and Ring Expansion in the Thermal Decomposition of a Divanadium(III) Complex With Four Bridging Methyl Groups

Chemistry – A European Journal, EarlyView.
Thermolysis of [{VCp*(µ‐CH3)2}2] (Cp* = η5‐C5Me5) in hexane leads to a tetranuclear cube‐type methylidene complex [{VCp*(µ3‐CH2)}4], while in benzenic solvents C6H5R produces the formal insertion of a CH fragment into the six‐membered aromatic ring of a solvent molecule to give trovacene derivatives with η7‐cycloheptatrienyl ligands [VCp*(η7‐C7H6R ...
Adrián Calvo‐Molina, Rodrigo González‐Prieto, Jesús Jover, Adrián Pérez‐Redondo, José Luis Priego, Carlos Yélamos   +5 more
wiley   +1 more source

Feasibility of a counter-current extraction procedure for the removal of heavy metals from contaminated soils [PDF]

, 1996
Masscheleyn, Patrick, Tack, Filip, Verloo, Marc   +2 more
core   +1 more source

Room‐Temperature Helix‐to‐Disc Conversion of Thia[6]helicene S,S‐Dioxides to Coronene via In Situ Phenoxide Anion Generation

Chemistry – A European Journal, EarlyView.
In situ phenoxide formation at the benzene terminus triggers room‐temperature conversion of thia[6]helicene S,S‐dioxides to coronene. The solubility contrast drives product precipitation, enabling isolation by simple filtration. This pericyclic annulation between the helical termini provides direct access to coronene‐type planar architectures ...
Kaito Seino, Takashi Murase
wiley   +1 more source

Assessment of lime treatment of expansive clays with different mineralogy at low and high temperatures

, 2019
Hatim Ali, Mostafa Mohamed
openalex   +2 more sources

Growth, yield and grain nutrients response of wheat (Triticum aestivum L.) to biochar, lime and farmyard manure amendment of the croplands in southern Ethiopia. [PDF]

, 2020
Mekdes Lulu, Bekele Lemma, Legesse Hidoto   +2 more
openalex   +1 more source