Results 141 to 150 of about 8,955,654 (340)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

YIDDISH PREFIXED VERBS WITH AVEK-: A COGNITIVE SEMANTIC CLASSIFICATION

Вестник Кемеровского государственного университета, 2013
This article introduces a cognitive-semantic classification of Yiddish prefixed verbs with avek-. It takes into account the spatial etymology of the prefix and considers the prefixed verbs from the standpoint of the semes acquired by virtue of the ...
K. A. Shishigin
doaj  

Limite inverznih limit

, 2013
V doktorski disertaciji se obravnava vprašanje ali iz konvergence grafov navzgor polzveznih veznih funkcij sledi konvergenca ustreznih pripadajočih inverznih limit za konstantna inverzna zaporedja kompaktnih metričnih prostorov. V uvodnem delu se vpeljejo osnovni pojmi kot so navzgor polzvezne funkcije, inverzna zaporedja in inverzne limite.
openaire   +1 more source

Reliability Analysis for Limit State Design of Shallow Foundation in Sandy Soil

, 2016
Sun Il Kim, Dong Gun Kim, Nam Jae Yoo
openalex   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The man in proverbs [PDF]

Diversitate si Identitate Culturala in Europa
The essay proposes an interpretation of proverbs as condensed forms of practical thought, organised by a proverbial reason articulated through three interdependent dimensions: functional, cognitive and expressive.
Ioan MILICĂ
doaj  

Exploring the Limits of Open Quantum Dynamics I: Motivation, New Results from Toy Models to Applications [PDF]

, 2020
Thomas Schulte‐Herbrüggen, Frederik vom Ende, Gunther Dirr   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source