Results 91 to 100 of about 6,599,785 (249)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Finding and breaking the realistic rate-distance limit of continuous variable quantum key distribution

, 2018
In this work, the rate-distance limit of continuous variable quantum key distribution is studied. We find that the excess noise generated on Bob's side and the method for calculating the excess noise restrict the rate-distance limit.
Guo, Siyou, Wang, Pu, Wang, Xuyang
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

First upper limit analysis and results from LIGO science data: stochastic background

, 2004
I describe analysis of correlations in the outputs of the three LIGO interferometers from LIGO's first science run, held over 17 days in August and September of 2002, and the resulting upper limit set on a stochastic background of gravitational waves. By
Abbot B (LIGO Scientific Collaboration), Abbot B (LIGO Scientific Collaboration), Abbot B (LIGO Scientific Collaboration), Abbot B (LIGO Scientific Collaboration), Abbot B (LIGO Scientific Collaboration), Adhikari R, Allen B, Allen B, Allen B J A Marck J P Lasota, Allen B Romano J D, Astone P, Astone P E Coccia G Pizzella G Veneziano, Christensen N, Compton C Nicholson D Schutz B F R T Jantzen G M Keiser, Flanagan É É, Flanagan É É, John T Whelan (for the LIGO Scienti Collaboration), Kolb E W, Maggiore M, Maggiore M, Whelan J T, Whelan J T   +21 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Unsupervised Deep Learning for Advanced Forming Limit Analysis in Sheet Metal: A Tensile Test-Based Approach. [PDF]

Materials (Basel), 2023
Thamm A, Thamm F, Sawodny A, Zeitler S, Merklein M, Maier A.   +5 more
europepmc   +1 more source

High performance interior point methods for three-dimensional finite element limit analysis [PDF]

, 2019
The ability to obtain rigorous upper and lower bounds on collapse loads of various structures makes finite element limit analysis an attractive design tool.
Lyamin, Andrei V., Podlich, Nathan, Sloan, Scott W.   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Study on upper bound limit analysis of horizontal layers slope stability based on optimization method. [PDF]

Sci Rep, 2023
Yao Y, Wang Z.
europepmc   +1 more source