Results 251 to 260 of about 2,230,220 (315)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Biological variation of baseline serum cortisol concentration in healthy dogs, part 2: clinical applications. [PDF]

Front Vet Sci
Wicker S, Craig S, Albright JD, Springer C, Freeman K, Giori L.   +5 more
europepmc   +1 more source

On-body measure of reaction time correlates with intoxication level. [PDF]

PLoS One
Blackwell MH, Valk HL, Eaton J, Kovaly SJ, Karnes SJ, Vu T, Stevenson KM, Kowalczyk MP, Gormley WB.   +8 more
europepmc   +1 more source

Comprehensive analysis of cefuroxime-associated adverse events: Insights from JADER database (2004-2024) and comparison with FAERS database. [PDF]

Medicine (Baltimore)
Li F, Luo J, Zhang X, Jiang C, Xia G.
europepmc   +1 more source

Effects of combinatorial hurdles on a non-alcoholic beer matrix challenged with <i>Salmonella</i> Javiana<i>, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, and Bacillus cereus</i>. [PDF]

Front Microbiol
Maust A, Desiree K, Rubinelli PM, Ferreira S, Acuff JC, Lafontaine S.   +5 more
europepmc   +1 more source

Development and Validation of a UV-Vis Spectrophotometric Method for the Determination of Hispidulin, Verbascoside, and Isoverbascoside in Sesewanua (<i>Clerodendrum Fragrans</i> Willd.) Fraction and Its Application to Dissolving Microneedle Formulations. [PDF]

ACS Omega
Sapiun Z, S Mohamad SNF, Imran AK, Kamba V, Wicita PS, Jahja SR, Yunus FAM, Mukhriani M, Daud RPA, Rasyid FA, Paneo MA, Ysrafil Y, Masrif M, Pangalo P.   +13 more
europepmc   +1 more source