Results 41 to 50 of about 1,086,889 (297)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Comparative analysis of stability of large diameter steel cylinder based on FEM and limit equilibrium [PDF]

E3S Web of Conferences, 2020
The stability mechanism of large-diameter steel cylinder under fill load has not yet formed a complete theory. In order to calculate the stability of the steel cylinder island arm structure in a certain project, the limit equilibrium and finite element ...
Yu Chang-yi, Lu Ming-yue
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effects of system-bath entanglement on the performance of light-harvesting systems: A quantum heat engine perspective [PDF]

, 2015
We explore energy transfer in a generic three-level system, which is coupled to three non-equilibrium baths. Built on the concept of quantum heat engine, our three-level model describes non-equilibrium quantum processes including light-harvesting energy ...
Cao, Jianshu, Wang, Chen, Xu, Dazhi, Zhao, Yang   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Large-area slope stability analysis: Performance comparison of three-dimensional limit equilibrium methods

Soils and Foundations
3D limit equilibrium methods (LEMs) for assessing slope stability over large areas have been applied in some studies (e.g., Tran et al., 2018; He et al., 2018).
Daichi Sugo, John Y. Choe, Saneiki Fujita, Nilo Lemuel J. Dolojan, Kenta Tozato, Reika Nomura, Kenjiro Terada, Eiji Tominaga, Shoji Iwanaga, Shuji Moriguchi   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Response of non-equilibrium systems at criticality: Exact results for the Glauber-Ising chain

, 1999
We investigate the non-equilibrium two-time correlation and response functions and the associated fluctuation-dissipation ratio for the ferromagnetic Ising chain with Glauber dynamics. The scaling behavior of these quantities at low temperature and large
Baxter R J, Bouchaud J P, Bouchaud J P, Bray A J, Bray A J, Bray A J, C Godrèche, Cox J T, Cugliandolo L F, Cugliandolo L F, Erdélyi A, Erdélyi A, Franz S, Glauber R J, Godrèche C, Godrèche C, J M Luck, Janssen H K, Langer J S, Prados A, Vincent E, Vincent E   +21 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

3D Limit Equilibrium Stability Analysis of Concave and Convex Slopes Considering Kinematic Constraints

Shock and Vibration, 2022
In the previous limit equilibrium stability analyses of concave and convex slopes, the kinematic constraints are not considered in the generation of slip surfaces. To tackle this problem, this technical note proposes a method to compute safety factors of
Xing-Pei Kang, Ya-Fei Wang, Zhan-Rong Zhang, Hao Xie, Yun Yang   +4 more
doaj   +1 more source