Results 61 to 70 of about 939,061 (246)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Analysis method for limit displacement based on displacement-associated stability of piled soil slopes

Yantu gongcheng xuebao
The classic limit equilibrium method cannot make a connection between slope stability and its displacement, and does not solve the limit displacement for the slope from a stable state to the limit state.
WU Bing1 , LI Shaohong2, XIAO Shiguo2 , LIANG Yao3
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Comparison of Limit Equilibrium and Finite Element Method for Slope Stability Analysis

Buildings
Slope stability is a critical and extensively researched topic that is important in structural design, especially when slopes are located near residential or civil engineering structures, as human lives are at risk.
Slavka Harabinova, Kamila Kotrasova, Eva Panulinova   +2 more
doaj   +1 more source

METODE KESEIMBANGAN BATAS vs METODE ELEMEN HINGGA UNTUK ANALISIS PONDASI DANGKAL MENERUS PADA TANAH KOHESIF [PDF]

, 2008
The most common analysis methods on shallow foundation are Terzaghi, Meyerhof, and Vesic. All of them are based on limit equilibrium, when the foundation starting to failure by applying maximum load.
Purwana, Yusep Muslih, Pramugani, Ahsin, Setiawan, Wahyu   +2 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Distribution of occupation numbers in finite Fermi-systems and role of interaction in chaos and thermalization

, 1996
New method is developed for calculation of single-particle occupation numbers in finite Fermi systems of interacting particles. It is more accurate than the canonical distribution method and gives the Fermi-Dirac distribution in the limit of large number
A. Bohr, F. M. Izrailev, F. Reif, V. V. Flambaum   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Thermodynamics of quantum jump trajectories in systems driven by classical fluctuations

, 2010
The large-deviation method can be used to study the measurement trajectories of open quantum systems. For optical arrangements this formalism allows to describe the long time properties of the (non-equilibrium) photon counting statistics in the context ...
A. Barchielli, Adrián A. Budini, D. F. Walls, H. J. Carmichael, H. P. Breuer, K. Binder, L. E. Reichl, L. Mandel, N. G. van Kampen   +8 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source