Results 41 to 50 of about 80,538 (311)

Teaching science and mathematics to students with visual impairments: Reflections of a visually impaired technician

open access: yesAfrican Journal of Disability, 2015
This study reports on factors that limit the participation of blind and partially sighted learners in mathematics and science education. Since the teacher, still remains one of the most crucial factors in any education system, the researcher deemed it ...
Mbulaheni Maguvhe
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

The concept of finite limit of a function at one point as explained by students of non-compulsory secondary education [PDF]

open access: yes, 2012
We review various educational studies of the mathematical concept of limit of a function at a point that indicate how colloquial uses of the terms “to approach,” “to tend toward,” “to reach,” “to exceed” and “limit” influence students’ conceptions of ...
Ruiz Hidalgo, Juan Francisco   +5 more
core  

The impact of CT-integrated mathematics instruction on secondary school students' computational thinking skills

open access: yesActa Psychologica
Cultivating students' computational thinking (CT) has become an educational priority, with the implementation of effective instructional programs identified as a key means of fostering these skills.
Huifen Xu   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A metric approach to limit operators

open access: yes, 2017
We extend the limit operator machinery of Rabinovich, Roch, and Silbermann from Z^N to (bounded geometry, strongly) discrete metric spaces. We do not assume the presence of any group structure or action on our metric spaces.
Spakula, Jan, Willett, Rufus
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Comparing the finite and infinite limits of sequences and functions: A mathematical and phenomenological analysis and its implications in Spanish textbooks

open access: yesPythagoras
The purpose of this article is to conduct a mathematical and phenomenological comparison of three concepts: (1) the finite limit of a function at a point, (2) the finite limit of a sequence, and (3) the infinite limit of a sequence.
Mónica Arnal-Palacián   +2 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

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