Results 171 to 180 of about 906,148 (267)

The Limit of Detection Matters: The Case for Benchmarking Severe Acute Respiratory Syndrome Coronavirus 2 Testing. [PDF]

Clin Infect Dis, 2021
Arnaout R, Lee RA, Lee GR, Callahan C, Cheng A, Yen CF, Smith KP, Arora R, Kirby JE.   +8 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Exploring bias due to below-limit-of-detection values in influenza vaccine antibody modeling: A case study and instructional guide for the CIVIC study. [PDF]

Vaccine
Ge Y, Handel A, Giabbanelli PJ, Lemacks J, Greer T, Raynee P, Bahl J, Skarlupka AL, Dobbin KK, Ross TM, Shen Y.   +10 more
europepmc   +1 more source

A handheld luminometer with sub-attomole limit of detection for distributed applications in global health

, 2023
Lebel P, Elledge S, Wiener DM, Jeyakumar I, Phelps M, Jacobsen A, Huynh E, Charlton C, Puccinelli R, Mondal P, Saha S, Tato CM, Gómez-Sjöberg R.   +12 more
europepmc   +1 more source

Low limit of detection of the AlGaN/GaN-based sensor by the Kelvin connection detection technique. [PDF]

Microsyst Nanoeng, 2021
Zhang H, Gan Y, Yang S, Sheng K, Wang P.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Clinical utility of companion diagnostic biomarker results below the limit of detection in comprehensive genomic profiling of patients with advanced non-small cell lung cancer. [PDF]

Oncologist
Li G, Greene SB, Kaur B, Keller-Evans RB, Graf RP, Decker B, Smith DL, Huang RSP.   +7 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nano-Photonic Crystal D-Shaped Fiber Devices for Label-Free Biosensing at the Attomolar Limit of Detection. [PDF]

Adv Sci (Weinh)
Del Villar I, Gonzalez-Valencia E, Kwietniewski N, Burnat D, Armas D, Pituła E, Janik M, Matías IR, Giannetti A, Torres P, Chiavaioli F, Śmietana M.   +11 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source