Methods to determine limit of detection and limit of quantification in quantitative real-time PCR (qPCR). [PDF]
Biomol Detect Quantif, 2017 Quantitative Real-Time Polymerase Chain Reaction, better known as qPCR, is the most sensitive and specific technique we have for the detection of nucleic acids.
Forootan A +5 more
europepmc +4 more sources
The lower limit of quantification in pharmacokinetic analyses. [PDF]
Journal of Veterinary Pharmacology and Therapeutics, 2019 Pharmacokinetic (PK) analyses rely fundamentally on independent measurements of drug concentrations in biological matrices, traditionally using chromatographic analytical methods. These methods have imperfect performance and introduce measurement error to the experiment.
A. Woodward, T. Whittem
semanticscholar +4 more sources
Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses. [PDF]
Pharmacol Res Perspect, 2015 Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in parameter estimation.
Keizer RJ +6 more
europepmc +2 more sources
Limit of Blank (LOB), Limit of Detection (LOD), and Limit of Quantification (LOQ)
Organic & Medicinal Chemistry International Journal, 2018 For any analytical method development and validation, it is require developing arobust, accurate, precise, and linear method which is the heart for the development activities for drug product and drug substances.
Mohamad Taleuzzaman
semanticscholar +2 more sources
Quantification of the information limit of transmission electron microscopes. [PDF]
Physical Review Letters, 2008 The resolving power of high-resolution transmission electron microscopes is characterized by the information limit, which reflects the size of the smallest object detail observable with a particular instrument. We introduce a highly accurate measurement method for the information limit, which is suitable for modern aberration-corrected electron ...
Juri Barthel, A. Thust
semanticscholar +4 more sources
Limit of detection and limit of quantification development procedures for organochlorine pesticides analysis in water and sediment matrices. [PDF]
Chem Cent J, 2013 BackgroundReliable values for method validity of organochlorine pesticides determination were investigated, in water by solid phase extraction and in sediment by Soxhlet extraction, followed by gas chromatography equipped with an electron capture ...
Saadati N +5 more
europepmc +2 more sources
Limit of Detection and Limit of Quantification Determination in Gas Chromatography
, 2014 Any year, millions of analyses of any kind are performed around the world, and millions of decisions are made, based on these analyses; have the medicaments, the amount of drug reported in their container?, Can we safely consume this water or these foods?
E. Bernal
semanticscholar +4 more sources
Multiple linear regression modeling with values below a lower limit of quantification – a statistical method comparison [PDF]
BMC Medical Research MethodologyBackground Missing values occur in almost all real-world medical data. Sometimes, more information is available for the missing values due to technical measurement limits.
Lorena Hafermann +4 more
doaj +2 more sources
Dual-Energy CT: Lower Limits of Iodine Detection and Quantification. [PDF]
Radiology, 2019 Background Assessments of the quantitative limitations among the six commercially available dual-energy (DE) CT acquisition schemes used by major CT manufacturers could aid researchers looking to use iodine quantification as an imaging biomarker. Purpose
M. Jacobsen +7 more
semanticscholar +3 more sources
PLoS ONE, 2017 Meat products often consist of meat from multiple animal species, and inaccurate food product adulteration and mislabeling can negatively affect consumers.
Yicun Cai +5 more
doaj +2 more sources