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How Well Quantified Is the Limit of Quantification?
Epidemiology, 2010Raw data on the relationship between known and measured values of an analyte are collected and analyzed to determine the limit of quantification (LOQ) of an assay. In most LOQ problems, the researcher is given an observed value for the marker of interest if this value is greater than the LOQ, and a missing value (
Ying, Guo +2 more
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SSRN Electronic Journal, 2014
The problem of nonquantifiability is a recurrent one in both public policy and ordinary life. Much of the time, we cannot quantify the benefits of potential courses of action, or the costs, or both, and we must nonetheless decided whether and how to proceed.
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The problem of nonquantifiability is a recurrent one in both public policy and ordinary life. Much of the time, we cannot quantify the benefits of potential courses of action, or the costs, or both, and we must nonetheless decided whether and how to proceed.
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Performance limits of LWIR gaseous plume quantification
SPIE Proceedings, 2011The central parameter in the quantification of chemical vapor plumes via remote sensing is the mean concentrationpath length (CL) product, which can lead to estimates of the absolute gas quantity present. The goal of this paper is to derive Cramer-Rao lower bounds on the variance of an unbiased estimator of CL in concert with other parameters of a ...
Steven E. Golowich +1 more
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Estimation of the uncertainty of the quantification limit
Spectrochimica Acta Part B: Atomic Spectroscopy, 2014Abstract A method to compute the standard deviation of detection and quantification limits based on an easy equation was proposed. The results were compared to those coming from the rigorously theoretical approach proposed in the literature which required quite complex computations.
BADOCCO, DENIS +3 more
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On the limits of infants' quantification of small object arrays
Cognition, 2005Recent work suggests that infants rely on mechanisms of object-based attention and short-term memory to represent small numbers of objects. Such work shows that infants discriminate arrays containing 1, 2, or 3 objects, but fail with arrays greater than 3 [Feigenson, L., & Carey, S. (2003).
Lisa, Feigenson, Susan, Carey
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Determining limit of quantification in microbiology
EJPPS EUROPEAN JOURNAL OF PARENTERAL AND PHARMACEUTICAL SCIENCESThe determination of limit of quantification (LOQ) is one of the tasks specified in the validation process of a microbiological method. So far a detailed procedure for doing it is still lacking. Given the LOD (limit of detection), or data for estimating the LOD, we propose a procedure for determining the LOQ based on a Poisson confidence interval and ...
Jianping Jiang, E Albert, null Parker
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Overcoming the Limits of Quantification by Visualization
Biological Theory, 2015Biological sciences have strived to adopt the conceptual framework of physics and have become increasingly quantitatively oriented, aiming to refute the assertion that biology appears unquantifiable, unpredictable, and messy. But despite all effort, biology is characterized by a paucity of quantitative statements with universal applications ...
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Automated quantification of myocardial perfusion SPECT using simplified normal limits
Journal of Nuclear Cardiology, 2005To simplify development of normal limits for myocardial perfusion SPECT (MPS), we implemented a quantification scheme in which normal limits are derived without visual scoring of abnormal scans or optimization of regional thresholds.Normal limits were derived from same-day TI-201 rest/Tc-99m-sestamibi stress scans of male (n = 40) and female (n = 40 ...
Piotr J, Slomka +7 more
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Quantification of Early Subclinical Limited Joint Mobility in Diabetes Mellitus
Diabetes Care, 1985Limited joint mobility (LJM) has been described in juvenile diabetic patients by Rosenbloom et al.; similar abnormalities are also present in adult diabetes. This modification may be associated with a high risk of microvascular complications. We tested the use of a goniometer in measuring subclinical joint limitation in 50 adult diabetic patients ...
G, Slama +5 more
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Evaluation of Approximate Methods for Calculating the Limit of Detection and Limit of Quantification
Environmental Science & Technology, 1999In a previous paper, a computational method was presented for determining statistically rigorous limits of detection and quantification. The main purpose of this study is to evaluate similar but less computationally complex methods. These approximate methods use data at multiple spiking concentrations, are iterative, can be derived from either ...
Michael E. Zorn +2 more
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