Results 41 to 50 of about 525,362 (303)

Challenges for cysteamine stabilization, quantification, and biological effects improvement

open access: yesJournal of Pharmaceutical Analysis, 2020
The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of ...
C. Atallah   +2 more
semanticscholar   +1 more source

Quantification of joint mobility limitation in adult type 1 diabetes

open access: yesFrontiers in Endocrinology, 2023
Aims Diabetic cheiroarthropathies limit hand mobility due to fibrosis and could be markers of a global profibrotic trajectory. Heterogeneity in definitions and lack of a method to measure it complicate studying associations with organ involvement and treatment outcomes.
Sanat Phatak   +12 more
openaire   +3 more sources

Development and validation of an UV-Vis spectrophotometric method for the quantification of oclacitinib in capsule formulation

open access: yesRevista de Ciências Farmacêuticas Básica e Aplicada, 2021
Objective. The aim of this study was the development and validation of an UV-Vis spectrophotometric method for the quantification of oclacitinib in commercial capsule formulation since pharmacopeias have not yet provided an official monograph for this ...
Danilo R. O. Momade   +7 more
doaj   +2 more sources

Validation of HPLC Method for the Determination of 5-hydroxymethylfurfural in Pestil, Köme, Jam, Marmalade and Pekmez

open access: yesHittite Journal of Science and Engineering, 2016
This study represents a high performance liquid chromatography HPLC method for the detection of 5-hydroxymethylfurfural in pestil, köme, jam and pekmez samples.
Cemalettin Baltacı, Zeynep Akşit
doaj   +1 more source

OPTIMIZATION OF PESTICIDES RESIDUES ANALYTICAL CONTROL IN CEREAL CROPS PROTECTION SYSTEM

open access: yesМедична наука України, 2019
Relevance. The scientific substantiation of the method selection, the development of conditions for qualitative identification and quantitative determination of Axial 050 EC, Peak 75 WG, Tilt 250 EC, Magnello 350 EC, Enzhio 247 SS, Karate Zeon 050 CC ...
M.M. Korshun   +5 more
doaj   +1 more source

Validation of an HPLC-UV method for the identification and quantification of bioactive amines in chicken meat

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016
A high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method was validated for the study of bioactive amines in chicken meat. A gradient elution system with an ultraviolet detector was used after extraction with trichloroacetic ...
D.C.S. Assis   +9 more
doaj   +1 more source

Analyzing siRNA Concentration, Complexation and Stability in Cationic Dendriplexes by Stem-Loop Reverse Transcription-qPCR

open access: yesPharmaceutics, 2022
RNA interference (RNAi) is a powerful therapeutic approach for messenger RNA (mRNA) level regulation in human cells. RNAi can be triggered by small interfering RNAs (siRNAs) which are delivered by non-viral carriers, e.g., dendriplexes.
Maximilian Neugebauer   +5 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

A multi-analyte LC-MS/MS method for screening and quantification of nitrosamines in sartans

open access: yesJournal of Food and Drug Analysis, 2020
An incident of sartan medicine contamination was notified by Europe in June 2018. The contaminant was identified as a probable carcinogenic nitrosamine and the recalls of sartan medicines were soon made.
Shu-Han Chang   +9 more
semanticscholar   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman   +17 more
wiley   +1 more source

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