Results 121 to 130 of about 10,153,724 (337)

An Integrated Approach to Government Financial Policy [PDF]

open access: yes
In this paper, I address three questions of government financial policy: how should a government’s aversion to financial risk be determined, when are new financial investments justified, and what is the optimal level of reserves in a flexible exchange ...
Jeff Huther
core  

Neutrino Physics from New Measurements

open access: yes, 2004
Emergence of neutrino physics is fueled by the recent growth in quality and quantity of experimental data, yet, there are still open questions. How much can the determination of mixing parameters be improved?
Yuksel, H.
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Representing the Lived Parents’ Experience of How to Answer the Religious Questions of Their Primary School Children

open access: yesمسائل کاربردی تعلیم و تربیت اسلامی, 2021
Objective: This study aimed to identify how parents can answer to their children’s religious questions. Method: To achieve this objective, the phenomenological method was used.
somayeh Gholami, Mohammad Hosseini
doaj  

Religious Education in the Search for Answers to Existential Human Questions

open access: yesPaedagogia Christiana, 2018
There are various ways in which man tries to reach a satisfactory answer to his questions about where he comes from, what he is aiming at, what the purpose and meaning of his life is. These questions are usually called existential questions.
Zbigniew Marek
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Sovereignty over Land and Sea in the Arctic Area

open access: yesAgenda Internacional, 2016
The paper reviews the claims over land and waters in the Arctic area. While almost all the disputes over land have today been settled, several questions relating to law of the sea are still pending.
Tullio Scovazzi
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Limit of Detection and Limit of Quantification Determination in Gas Chromatography

open access: yes, 2014
Any year, millions of analyses of any kind are performed around the world, and millions of decisions are made, based on these analyses; have the medicaments, the amount of drug reported in their container?, Can we safely consume this water or these foods?
E. Bernal
semanticscholar   +1 more source

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