Results 61 to 70 of about 1,651,766 (269)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
PLEA BARGAINING IN BRAZIL: WHAT ARE ITS LIMITS?
Revista Eletrônica de Direito Processual, 2016 The present study aims to critically analyze plea bargaining in Brazil, with special concern to its limits of application.
Afranio Silva Jardim
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
European Journal for Philosophy of Science, 2018 Humeans take reality to be devoid of 'necessary connections': things just happen. Laws of nature are to be understood in terms of what 'just happens', not vice versa. Here the Humean needs some conception of what it is that 'just happens' - a conception of the Humean mosaic.
openaire +4 more sources
Water Management for Sustainable Growth Strategies
Visegrad Journal on Bioeconomy and Sustainable Development, 2016 The aim of this document is to present a synthesis of water sustainability issues as the basic role in the sustainable growth strategies in many countries.
Jurík Ľuboš +2 more
doaj +1 more source
Consideraciones en torno al recursos de interpretación constitucional
Revista de Derecho Político, 2009 La Constitución de la Republica Bolivariana de Venezuela, del año 1999, reconoció su carácter de norma suprema y creó una Sala Constitucional en el Tribunal Supremo de Justicia con el objeto de que ejerza la jurisdicción constitucional en un modelo donde
Angela Figueruelo
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source