Results 81 to 90 of about 64,070 (252)

The Limits of Knowledge

World Journal of Advanced Research and Reviews
The definition of knowledge encompasses various meanings, from the process by which we have the perception of the outside world, through the stimuli that we receive from this, when that perception becomes part of our system of awareness and experience.
Bruno Riccardi, Sergio Resta, Giacomo Resta   +2 more
openaire   +3 more sources

Is Information a Sufficient Basis for Cognition? Part 1: Critique of Dretske’s Approach

tripleC: Communication, Capitalism & Critique, 2011
Based upon the natural limits of observation, we tackle a critical review of Dretske’s approach to information, knowledge and perception. The physics of the manifestation of an arbitrary object –tackled in Part 2 as a separate article– sets forth an ...
José María Díaz Nafría, Mario Pérez-Montoro   +1 more
doaj   +1 more source

The Limits to Transforming the Environment and the Limits to Sociological Knowledge [PDF]

Sustainability, 2010
This paper argues that the social sciences are fragmented in addressing the environmental challenge of increasing resource depletion. To address this problem, the paper puts forward a framework which encompasses several disciplinary approaches, and above all a long-term historical perspective and a realist sociology of science and technology which, in ...
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Knowledge Flows, Learning and Development in an International Context [PDF]

, 2012
In the editorial of this special issue we argue that knowledge flows, learning and development are becoming increasingly important in all organisations operating in an international context.
Patel, Charmi, Budhwar, P, Theodorakopoulos, Nicholas, Patel, Charmi; id_orcid, Budhwar, Pawan, Theodorakopoulos, N, Budhwar, Pawan S.   +6 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

STUDENTS’ CONCEPTUAL KNOWLEDGE OF LIMITS IN CALCULUS: A TWO-PART CONSTRUCTIVIST CASE STUDY [PDF]

, 2013
This case study investigated students’ conceptual knowledge of limits in calculus by implementing semi-structured interviews. The constructivist learning principles of Piaget and Inhelder as well as theories of understanding by Skemp guided the study. In
NC DOCKS at The University of North Carolina at Charlotte, Adams, Margaret Smolinka   +1 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Limits to Knowledge: Indigenous Peoples, NGOs, and the Moral Economy in the Eastern Amazon of Brazil

Conservation & Society, 2014
Despite widespread recognition of the importance of community-conservation partnerships, problems continue to emerge. In this paper we examine one such interaction to propose that outside organisations have wrongly associated the delimitations of the ...
Janet Chernela, Laura Zanotti
doaj   +1 more source