Results 111 to 120 of about 167,013,277 (277)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Applied SciencesThis study focuses on the reliability assessment of a series system composed of Weibull-distributed components. Because high-reliability components rarely fail during life testing or actual operation, conventional system reliability analysis methods ...
Ziang Li, Huimin Fu, Jianchao Guo
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Forest landscape mosaics: disturbance, restoration and management at times of global change : [international conference], 11-14 August 2014 Tartu, Estonia : book of abstracts [PDF]
, 2014 KonverentsikogumikThe nature which surrounds us plays a central role in our existence. This is difficult to comprehend, as usually we place ourselves at the center of human existence.
Estonian University of Life Sciences
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Critical Decision Thresholds for Urgent Physician Notification of Point-of-Care Testing Results
DiagnosticsBackground/Objectives: Critical limits define quantitative thresholds for life-threatening diagnostic test results that require immediate clinician notification and may prompt urgent intervention to prevent adverse outcomes.
Kami Osher, Gerald J. Kost
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Linguae &: Rivista di Lingue e Culture Moderne, 2009 Autobiography and life-writing are two opposite forms to represent the self: while the former is inextricably bound to assumptions of coherent subjectivity, wholeness of sight and universal validity, the latter leaves room for doubt and contradiction and
Sandra Lila Maya Rota
doaj