Results 121 to 130 of about 3,283,746 (296)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Reliability Assessment of a Series System with Weibull-Distributed Components Based on Zero-Failure Data

Applied Sciences
This study focuses on the reliability assessment of a series system composed of Weibull-distributed components. Because high-reliability components rarely fail during life testing or actual operation, conventional system reliability analysis methods ...
Ziang Li, Huimin Fu, Jianchao Guo
doaj   +1 more source

Conjoined Twins — The Limits of Law at the Limits of Life

New England Journal of Medicine, 2001
Conjoined twins have been the subject of scientific exhibits, medical study, human curiosity, and even entertainment, but until the year 2000, conjoined twins had never been the subject of a courtr...
openaire   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

In chaotropy lies opportunity

Frontiers in Microbiology, 2016
Mark Alexander Lever
doaj   +1 more source

Measurement of double beta decay of ¹⁰⁰Mo to excited states in the NEMO 3 experiment [PDF]

, 2007
The double beta decay of ¹⁰⁰Mo to the 0_{1}^{+} and 2_{1}^{+} excited states of ¹⁰⁰Ru is studied using the NEMO 3 data. After the analysis of 8024 h of data the half-life for the two-neutrino double beta decay of ¹⁰⁰Mo to the excited 0_{1}^{+} state is ...
Arnold, R, Augier, C, Baker, J, Barabash, AS, Bongrand, M, Broudin, G, Brudanin, V, Caffrey, AJ, Egorov, V, Etienvre, AI, Fatemi-Ghomi, N, Hubert, F, Hubert, P, Jerie, J, Jollet, C, Jullian, S, King, S, Kochetov, O, Konovalov, SI, Kovalenko, V, Lalanne, D, Lamhamdi, T, Leccia, F, Lemière, Y, Longuemare, C, Lutter, G, Marquet, C, Mauger, F, Nachab, A, Ohsumi, H, Perrot, F, Piquemal, F, Reyss, JL, Ricol, JS, Saakyan, R, Sarazin, X, Shitov, Y, Simard, L, Smolnikov, A, Suhonen, J, Sutton, CS, Szklarz, G, Söldner-Rembold, S, Thomas, J, Timkin, V, Tretyak, V, Umatov, V, Vanyushin, I, Vasiliev, V, Vorobel, V, Vylov, T, Vála, L, Šimkovic, F, Štekl, I   +53 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Critical Decision Thresholds for Urgent Physician Notification of Point-of-Care Testing Results

Diagnostics
Background/Objectives: Critical limits define quantitative thresholds for life-threatening diagnostic test results that require immediate clinician notification and may prompt urgent intervention to prevent adverse outcomes.
Kami Osher, Gerald J. Kost
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The limits of postcolonial autobiography and the empowering capacity of life-writing for the postcolonial subject

Linguae &: Rivista di Lingue e Culture Moderne, 2009
Autobiography and life-writing are two opposite forms to represent the self: while the former is inextricably bound to assumptions of coherent subjectivity, wholeness of sight and universal validity, the latter leaves room for doubt and contradiction and
Sandra Lila Maya Rota
doaj