Results 161 to 170 of about 8,257 (214)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
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Nature, 1992
How can the world's population be made more healthy? Study of the age distribution of diseases and causes of death in individual countries will enable nationally appropriate research and public-health priorities to be set.
P H, Lohman +2 more
openaire +2 more sources
How can the world's population be made more healthy? Study of the age distribution of diseases and causes of death in individual countries will enable nationally appropriate research and public-health priorities to be set.
P H, Lohman +2 more
openaire +2 more sources
On the decomposition of life expectancy and limits to life
Population Studies, 2015Life expectancy is a measure of how long people are expected to live and is widely used as a measure of human development. Variations in the measure reflect not only the process of ageing but also the impacts of such events as epidemics, wars, and economic recessions.
Les, Mayhew, David, Smith
openaire +2 more sources
German Research, 2014
AbstractProtozoa play a key role in the food webs of the oceans. Ecologists are seeking to understand the evolution and species diversity of microbial plankton — both in the laboratory and at the bottom of the hostile, low‐oxygen deep‐sea basins of the Mediterranean Sea.
Thorsten Stoeck, Lea Weinisch
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AbstractProtozoa play a key role in the food webs of the oceans. Ecologists are seeking to understand the evolution and species diversity of microbial plankton — both in the laboratory and at the bottom of the hostile, low‐oxygen deep‐sea basins of the Mediterranean Sea.
Thorsten Stoeck, Lea Weinisch
openaire +1 more source
Science, 1998
WASHINGTON, D.C.-- DNA, RNA, and the ribosomes that help translate the genetic code into proteins have a fixed size, which puts a limit on how small a self-replicating cell can be, according to a group of experts who gathered at the National Academy of Sciences last month to discuss the limits of life at the tiniest level.
openaire +2 more sources
WASHINGTON, D.C.-- DNA, RNA, and the ribosomes that help translate the genetic code into proteins have a fixed size, which puts a limit on how small a self-replicating cell can be, according to a group of experts who gathered at the National Academy of Sciences last month to discuss the limits of life at the tiniest level.
openaire +2 more sources
Upper Temperature Limit of Life
Science, 1963Samples of microorganisms from the hot springs of Yellowstone National Park have been collected and tested for the ability to utilize radioactive phosphorus. No evidence for growth was found above 73°C.
openaire +2 more sources