Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels. [PDF]
El-Feky AM +2 more
europepmc +1 more source
Lefamulin Overcomes Acquired Drug Resistance via Regulating Mitochondrial Homeostasis by Targeting ILF3 in Hepatocellular Carcinoma. [PDF]
Zheng Y +10 more
europepmc +1 more source
Network pharmacology combined with untargeted metabolomics reveals the intervention mechanism and compatibility of chenpi-rougui herb pair in nonalcoholic fatty liver disease. [PDF]
Xu J +6 more
europepmc +1 more source
AbstractLimonoids are highly oxygenated C13α‐triterpenes and common secondary metabolites. Several hundred congeners have been isolated to date. The first total synthesis of (±)‐limonin, the flagship congener of the limonoids, is now reported and features 1) a tandem radical cyclization generating the BCD ring system with the C13α configuration that is
Shuji, Yamashita +5 more
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Evaluation of the Antioxidant Capacity of Limonin, Nomilin, and Limonin Glucoside
Journal of Agricultural and Food Chemistry, 2006The antioxidant capacity (AOC) of three representative citrus limonoids, limonin, nomilin, and limonin glucoside, was examined by the oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), beta-carotene-linoleic acid bleaching, and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assays.
Andrew P, Breksa, Gary D, Manners
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Die Struktur desepi-Limonol-jodoacetates (C26H31O8) COCH2I, wurde durch dreidimensionale Rontgenanalyse bestimmt. Es gelang, die Lage samtlicher Atome in zwei kristallographisch unabhangigen, jedoch chemisch identischen Molekeln zu ermitteln. Dieses Resultat stellt eine vollstandige Bestimmung der Konstitution und der Stereochemie des Limonins dar.
S. Arnott +4 more
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Gender differences in limonin pharmacokinetics in rats
European Journal of Drug Metabolism and Pharmacokinetics, 2005In the present study, the pharmacokinetics of limonin (LM) were investigated in male and female rats. LM concentrations in the plasma were determined after the oral administration of 36 mg/kg LM or after intravenous (i.v.) injection of LM 3.6 mg/kg respectively.
Y, Liang +5 more
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Limonin ameliorates cardiovascular dysfunction and remodeling in hypertensive rats
Life Sciences, 2023Limonin is a tetracyclic triterpenoid isolated from citrus fruits. Here, the effects of limonin on cardiovascular abnormalities in nitric oxide-deficient rats induced by Nω-Nitrol-arginine methyl ester (L-NAME) were explored.Male Sprague Dawley rats were given L-NAME (40 mg/kg, drinking water) for 3 weeks and then treated daily with polyethylene glycol
Metee, Iampanichakul +6 more
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Degradation of limonin by entrappedRhodococcus fascians cells
Biotechnology Letters, 1989Limonin degradingRhodococcusfascians was immobilized by entrapment in alginate, k-carrageenan, agarose and polyacrylamide gels. Except this latter, gels were used both with and without polyethyleneimine treatment followed by glutaraldehyde crosslinking.
C. Mart�nez-Madrid +2 more
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An Improved Enzyme Immunoassay for Limonin
Journal of Food Science, 1988ABSTRACT Performance of the previously reported enzyme immunoassay for determination of limonin in citrus juice was improved by stabilization of anti‐limonin‐antibody‐coated microtitration wells with 1% solution of ovalbumin and polyvinyl alcohol.
BHANU P. RAM +3 more
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