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Lincomycin

BMJ, 1964
Lincomycin (Lincocin - Upjohn; Mycivin - Boots) is a new antibiotic with activity against Gram-positive bacteria. It was isolated by Upjohn in 1955 from Streptomyces lincolnensis. It is supplied as the hydrochloride, which is soluble in water.
A. A. B. Mitchell, J. J. Robertson
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Absorption of Lincomycin and Lincomycin Esters from Rat Jejunum

Journal of Pharmaceutical Sciences, 1968
The absorption of lincomycin equivalents from rat intestinal loops was improved when short-chain (3 and 4 carbons) fatty acid esters of the drug were used. The 7-butyrate and 7-propionate esters of lincomycin appear to be absorbed more efficiently than corresponding 2-esters.
H P, Fletcher, H M, Murray, T E, Weddon
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Modification of Lincomycin

1971
Publisher Summary The chapter gives an account of the modification of lincomycin. The fermentation broth of streptomyces lincolnensis var. lincolnensis, a new species of streptomycete isolated from a soil sample collected in Gering, Nebraska, was found to contain a new antibiotic, named lincomycin.
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The synthesis of lincomycin

Journal of the Chemical Society C: Organic, 1970
Methyl 6-amino-6,8-dideoxy-1-thio-D-erythro-α-D-galacto-octopyranoside(16), the intact carbohydrate portion of the antibiotic lincomycin (1), has been synthesised from D-galactose. The amino-alcohol side chain was attached to 1,2:3,4-di-O-isopropylidene-α-D-galacto-hexodialdopyranose-(1,5)(2) by two independent procedures, and the glycosidic thiomethyl
G B, Howarth, W A, Szarek, J K, Jones
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