Results 171 to 180 of about 11,220 (227)
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Journal of Pharmaceutical Sciences, 1965
Lincomycin degrades slowly in 0.1 N HCl at 70° (half-life, 39 hr.), and the decrease in optical rotation shows a direct correlation with microbiological assays. At 37°, lincomycin shows no degradation for at least 48 hr. in 0.1 N HCl. Under these conditions, penicillin V degrades with a half-life of 29 min.
A A, FORIST, L W, BROWN, M E, ROYER
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Lincomycin degrades slowly in 0.1 N HCl at 70° (half-life, 39 hr.), and the decrease in optical rotation shows a direct correlation with microbiological assays. At 37°, lincomycin shows no degradation for at least 48 hr. in 0.1 N HCl. Under these conditions, penicillin V degrades with a half-life of 29 min.
A A, FORIST, L W, BROWN, M E, ROYER
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Mass spectra of lincomycin, lincomycin analogs and degradation products
Organic Mass Spectrometry, 1972AbstractThe principal ions observed in the mass spectra of lincomycin hydrochloride, some of its analogs and two degradation products are discussed. Lincomycin‐related compounds can be characterized by examination of the molecular ion and four other ions. Plausible mechanistic interpretations of these ions are presented.
Fred Kagan, Marvin F. Grostic
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JAMA: The Journal of the American Medical Association, 1968
To the Editor:— We have been using large doses of lincomycin hyd o-chloride monohydrate (Lincocin) for the treatment of endocarditis (Arch Intern Med120:361, 1967) and severe staphylococcal infections and wish to bring to the immediate attention of fellow practitioners the fact that large doses of lincomycin, given rapidly, seem to be associated with ...
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To the Editor:— We have been using large doses of lincomycin hyd o-chloride monohydrate (Lincocin) for the treatment of endocarditis (Arch Intern Med120:361, 1967) and severe staphylococcal infections and wish to bring to the immediate attention of fellow practitioners the fact that large doses of lincomycin, given rapidly, seem to be associated with ...
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Oral Surgery, Oral Medicine, Oral Pathology, 1970
Abstract Lincomycin has proved to be an effective drug in treating staphylococcus infections. It is easy to administer orally and is well tolerated in doses of 500 mg. four times a day for prolonged periods of time. Its effectiveness against bone infections is attributed to its ability to penetrate bone and severely infected tissue.
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Abstract Lincomycin has proved to be an effective drug in treating staphylococcus infections. It is easy to administer orally and is well tolerated in doses of 500 mg. four times a day for prolonged periods of time. Its effectiveness against bone infections is attributed to its ability to penetrate bone and severely infected tissue.
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