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Results 101 to 110 of about 95,332 (230)

PD‐1/PD‐L1 in Hepatocellular Carcinoma (2014–2024): A Combined Macro and Micro Analysis of Immunotherapy Implications

iNew Medicine, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) represents a significant global health issue, with the PD‐1/PD‐L1 axis serving a pivotal target for immunotherapy in this malignancy. However, a comprehensive bibliometric analysis of PD‐1/PD‐L1 research in HCC is lacking.
Xingyu Zhu +4 more
wiley +1 more source

Experiences of Diagnostic Radiography Students With Workplace‐Based and Online Learning During the COVID‐19 Pandemic: A Study Across Four Higher Education Institutions in South Africa

Journal of Medical Radiation Sciences, EarlyView.
This study explored diagnostic radiography students' learning experiences during COVID‐19 across four South African Higher Education Institutions. Themes included challenges with clinical placements, PPE and online learning, as well as inclusive learning enablers. Findings inform strategies to support students during future crises.
Siyabonga Goodwill Hadebe, Amina Hajat, Lynne Janette Hazell +2 more
wiley +1 more source

Dose‐dependent association of systemic comorbidities with periodontitis severity: A large population cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley +1 more source

Characteristics of Adult Patients With Atopic Dermatitis Initiating Biologics and Janus Kinase Inhibitors in the CorEvitas Atopic Dermatitis Registry

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Biologics and Janus kinase inhibitors (JAKi) are two advanced systemic treatment options for patients with atopic dermatitis (AD). The decision to initiate one of these therapies is complex and may be driven by many factors.
Eric L. Simpson +12 more
wiley +1 more source

Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rosuvastatin (RVS) is an HMG‐CoA reductase inhibitor with lipid‐lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE−/− mice were fed a high‐fat diet to generate a mouse model of AS.
Xin Fu +5 more
wiley +1 more source

Usefulness of Gamma‐Glutamyl Transferase and Sequential Carbohydrate‐Deficient Transferrin for Unhealthy Alcohol Use Screening in Indigenous Communities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Unhealthy alcohol use (UAU) screening facilitates identification of patients with alcohol use problems for intervention. This study evaluates the usefulness of gamma‐glutamyl transferase (GGT) and sequential percentage of carbohydrate‐deficient transferrin (%CDT) in community screening for UAU.
Jing‐Houng Wang +6 more
wiley +1 more source

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin +8 more
wiley +1 more source

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen +4 more
wiley +1 more source

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

BMC Pharmacology and Toxicology, 2017
G. Todd Milne +479 more
doaj +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source

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