Results 191 to 200 of about 368,381 (286)

Combined cellular and biochemical profiling of Bruton's tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers. [PDF]

open access: yesFront Oncol
Kluitmans DJF   +8 more
europepmc   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

open access: yesExperimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela   +4 more
wiley   +1 more source

Sound offset responses become highly informative in the auditory cortex

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using large datasets of neural responses to diverse sounds recorded across four stages of the mouse auditory system (depicted and colour‐coded on the left), offset responses occurring after the termination of each sound (time window indicated by the orange shaded area superimposed with activity traces) were characterized and it ...
Charly Lamothe   +3 more
wiley   +1 more source

The Lindens

open access: yesBulletin of popular information - Arnold Arboretum, Harvard University., 1926
openaire   +1 more source

The what, which, when, why and who of Off responses in the auditory system

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In this article, we will first review ‘What’ different mechanisms are involved in the generation of Off responses at the sub‐cortical and cortical level of the auditory system. Then, we evaluate ‘Which’ stimulus properties elicit Off responses at the different levels of the auditory system.
Jean‐Marc Edeline, Robert C. Liu
wiley   +1 more source

Sound‐offset encoding is related to speech‐in‐noise perception at sentence level in older adults

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic summary of the study investigating sound‐onset and offset sensitivity in the brain of older adults. EEG responses to white‐noise bursts were recorded to examine neural encoding of sound onset and offset during passive listening and active task conditions.
Hasan Colak   +6 more
wiley   +1 more source

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