Results 191 to 200 of about 1,025,790 (266)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Quality of informal care among informal caregivers of people with dementia: A latent profile and ROC analysis. [PDF]

PLoS One
Cai C, Cheng B, Shi C, Shi W, Li C, Liu C, Sun J.   +6 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Thermophysics-Informed Phenomenological Framework for Molten Material Self-Organization in Laser Remelting-Based Surface Polishing: Conceptualization and Preliminary Analysis. [PDF]

Micromachines (Basel)
Bordatchev E.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

MetaComb: a meta-learning framework for drug combination response prediction from cell lines to patients. [PDF]

Front Genet
Guo C, Li T, Deng X, Ma Y, He F, Diao L, Wang Z, Li D, Liu Z.   +8 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Measuring inequality in quality of life: further evidence that the EQ-5D-5L may underestimate it. [PDF]

Qual Life Res
Lamu AN, Chen G, Cheng LJ, Olsen JA, EQ-DAPHNIE Project Team.   +4 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Bevacizumab and Paclitaxel in Advanced, Hormone Receptor-Positive Breast Cancer: Multifactor Dimensionality Reduction Methodology to Identify Best Overall Survival. [PDF]

Oncol Res
Coltelli L, Orlandi P, Finale C, Musettini G, Masini LC, Scalese M, Soria G, Sartori E, Nodari Y, Arrighi G, Bandini A, Banchi M, Tacchi C, Tang D, Salvadori B, Tanganelli L, Giovannelli S, Pistelli M, Cupini S, Lucchesi M, Cosimi A, Lorenzini G, Biasco E, Caparello C, Acconci G, Fontana E, Bona E, Farnesi A, Pellino A, Marini A, De Maio E, Stasi I, Barbara C, Sammarco E, Rosada J, Allegrini G, Bocci G.   +36 more
europepmc   +1 more source