Results 11 to 20 of about 4,813,932 (329)
ADAR1 restricts LINE-1 retrotransposition [PDF]
Nucleic Acids Research, 2016 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects. Concerning HIV-1, several studies showed that ADAR1 favors viral replication.
Orecchini, Elisa +9 more
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Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer [PDF]
Epigenetics, 2017 Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements.
Natasha Vafadar-Isfahani +10 more
doaj +4 more sources
Adaptive Evolution in LINE-1 Retrotransposons [PDF]
Molecular Biology and Evolution, 2001 We traced the sequence evolution of the active lineage of LINE-1 (L1) retrotransposons over the last approximately 25 Myr of human evolution. Five major families (L1PA5, L1PA4, L1PA3B, L1PA2, and L1PA1) of elements have succeeded each other as a single lineage. We found that part of the first open-reading frame (ORFI) had a higher rate of nonsynonymous
S, Boissinot, A V, Furano
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Schlafen-5 inhibits LINE-1 retrotransposition
iScience, 2023 Long interspersed element 1 (LINE-1) is the only currently known active autonomous transposon in humans, and its retrotransposition may cause deleterious effects on the structure and function of host cell genomes and result in sporadic genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we
Jiwei Ding +24 more
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Energies, 2021 The latest technologies for climate change mitigation are carbon capture and storage (CCS). Some countries are developing CCS projects, and they are currently at different stages of deployment.
Yurii Vasilev +3 more
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Journal of Marine Science and Engineering, 2023 The rise in anthropogenic impacts on the marine environment requires new water management. The use of a triadic approach (bioaccumulation, bioassay, and physiological biomarkers) has been shown to have good applicability for the comparative assessment of
Nadezhda Berezina +4 more
doaj +1 more source
LINE-1 Retroelements Get ZAPped! [PDF]
PLoS Genetics, 2015 An acute viral infection begins a cascade of events in host organisms. Primed by an interferon response, host cells dramatically increase the expression of hundreds of interferon-stimulated genes (ISGs) that collectively attempt to block the virus at various stages of its intracellular cycle.
Richard N McLaughlin, Harmit S Malik
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Regulation of LINE-1 in mammals [PDF]
Biomolecular Concepts, 2014 AbstractTransposable elements (TEs) are mobile DNA elements that represent almost half of the human genome. Transposition of TEs has been implicated as a source of genome evolution and acquisition of new traits but also as an origin of diseases. The activity of these elements is therefore tightly regulated during the life cycle of each individual, and ...
Bodak, Maxime +2 more
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Evolutionary history of LINE-1 in the major clades of placental mammals [PDF]
, 2016 BACKGROUND: LINE-1 constitutes an important component of mammalian genomes. It has a dynamic evolutionary history characterized by the rise, fall and replacement of subfamilies.
Dobigny, Gauthier +3 more
core +1 more source
4 open, 2019 The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
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