Results 191 to 200 of about 4,881,979 (331)

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain. [PDF]

Elife
Bonnifet T, Sinnassamy S, Massiani-Beaudoin O, Mailly P, Monnet H, Loew D, Lombard B, Servant N, Joshi RL, Fuchs J.   +9 more
europepmc   +1 more source

Discovery of two new isomers of cyanoacenaphthylene (C12H7CN) in TMC-1 with the QUIJOTE line survey

Cabezas, Carlos
openalex   +1 more source

Insights into the DNA cleavage mechanism of human LINE‐1 retrotransposon endonuclease

, 2008
Konstantinos Repanas, Gloria Fuentes, Serge X. Cohen, Alexandre M. J. J. Bonvin, Anastassis Perrakis   +4 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Regulation of LINE-1 in human cancers [PDF]

, 2014
Contreras Planesas, Beatriz, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Identification of novel regulators of LINE-1 expression via CRISPR/Cas9 screening. [PDF]

Mob DNA
Oksuz O, Chu C, Arisdakessian C, Diao L, Zaller D, Long KK, Keilhack H, Knutson S.   +7 more
europepmc   +1 more source

Mitochondrial Dysfunction Is Involved in Apoptosis Induced by Serum Withdrawal and Fatty Acids in the β-Cell Line Ins-1 [PDF]

, 2002
Isabel Maestre, Joaquı́n Jordán, Soledad Calvo, Juan A. Reig, Valentı́n Ceña, Bernat Soria, Marc Prentki, Enrique Roche   +7 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes

Biology Open
Alyssa Risner, Joyce Nair-Menon, Abhinav Cheedipudi, Joe R. Delaney, Vamsi Gangaraju, Antonis Kourtidis   +5 more
doaj   +1 more source