Results 191 to 200 of about 4,813,932 (329)

Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells [PDF]

, 2016
Gaël Cristofari, Javier G. Pizarro
core   +1 more source

Saliva Spectral Signature and LINE-1 Methylation in Oral Cells: Impact of Air Pollution in São Paulo State Residents. [PDF]

Scientifica (Cairo)
Nunes AR, Baroudi K, Jaber M, Carvalho LB, Toledo GDS, Pereira TM, de Carvalho LFCS, Fisch G, da Silva RAF.   +8 more
europepmc   +1 more source

In-line monitoring of a multi-stage drying process for battery electrodes: vol. 1—applying methods of scattered light measurement [PDF]

Jonas Mohacsi, Kevin Ly, Marius Birg, Philip Scharfer, Wilhelm Schabel   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Extracellularly Regulated Kinases 1/2 (p44/42 Mitogen-Activated Protein Kinases) Phosphorylate Synapsin I and Regulate Insulin Secretion in the MIN6 β-Cell Line and Islets of Langerhans [PDF]

, 2004
Christine Longuet, Christophe Broca, Safia Costes, El Habib Hani, D. Bataille, Stéphane Dalle   +5 more
openalex   +1 more source

Additional file 1 of Clinical implications of circulating tumor DNA in predicting the outcome of diffuse large B cell lymphoma patients receiving first-line therapy

, 2022
Miaomiao Li, Lan Mi, Chunyang Wang, Xiaojuan Wang, Jianhua Zhu, Fei Qi, Hui Yu, Yingying Ye, Dedao Wang, Jiaowu Cao, Dingyao Hu, Quanyu Yang, Dandan Zhao, Tonghui Ma, Yuqin Song, Jun Zhu   +15 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches. [PDF]

J Biol Chem
Miller BD, Smail BA, Van Eeuwen T, Kodama H, Kondo K, Jiang H, O'Brien A, Dai N, Trachman RJ, Guan S, Karlow JA, Cheng WC, Sedivy JM, Jogl G, Rout MP, LaCava J, Burns KH, Taylor MS.   +17 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation. [PDF]

PLoS Genet
Liu Q, Liu Y, Mao Y, Yi D, Li Q, Ding J, Guo S, Zhang Y, Wang J, Zhao J, Ma L, Peng X, Cen S, Li X.   +13 more
europepmc   +1 more source