Results 211 to 220 of about 28,196,398 (315)

Publisher Correction: Long-read technologies identify a hidden LINE-1/ERV1 insertion in IQCB1 as causative variant for Senior-Løken syndrome. [PDF]

NPJ Genom Med
de Bruijn SE, Ingeborgh VDBL, Derks R, Haer-Wigman L, O'Gorman L, Cremers FPM, van Beek R, Hoischen A, Roosing S, Neveling K.   +9 more
europepmc   +1 more source

lk27 [PDF]

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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation. [PDF]

PLoS Genet
Liu Q, Liu Y, Mao Y, Yi D, Li Q, Ding J, Guo S, Zhang Y, Wang J, Zhao J, Ma L, Peng X, Cen S, Li X.   +13 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches. [PDF]

J Biol Chem
Miller BD, Smail BA, Van Eeuwen T, Kodama H, Kondo K, Jiang H, O'Brien A, Dai N, Trachman RJ, Guan S, Karlow JA, Cheng WC, Sedivy JM, Jogl G, Rout MP, LaCava J, Burns KH, Taylor MS.   +17 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Assessment of references for the quantitative analysis of LINE-1 and Alu methylation in cellular DNA and circulating cell-free DNA of cancer patients. [PDF]

PLoS One
Pham TT, Vuong LD, Mai TV, Ho SV, Vu GS, Tran TTQ, Do TH, Pham OM, Nguyen LTT, Pham LTP, Vo LTT, Nguyen UQ.   +11 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence. [PDF]

Mob DNA
Munot D, Lu Y, Haußmann I, Najjar G, Baur C, Singh M, Günes C, Sauter D, Arora A.   +8 more
europepmc   +1 more source