Results 231 to 240 of about 4,881,979 (331)

STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation. [PDF]

EMBO Rep
Huang Y, Xu F, Wang L, Mei S, Zhao F, Wang L, Xie Y, Wei L, Hu Y, Gao Z, Xue T, Fang J, Guo F.   +12 more
europepmc   +1 more source

Long interspersed nuclear element-1 (line-1) hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma

, 2020
Yu Rim Lee, Gyeonghwa Kim, Hye Won Lee, Se Young Jang, Soo Young Park, Won Young Tak, Young Oh Kweon, Jung Gil Park, Min Kyu Kang, Keun Hur   +9 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LINE-1 transposition into murine Thyroglobulin results in congenital thyroid dysplasia. [PDF]

PLoS One
Bailey WJ, Smits BMG, Erdos Z, Gaspar JM, Lane P, Kuruvilla S, Rosahl TW, Thudium D, Wang J, Glaab WE, MacGowan M, Multari H, Cumo C, Navis A, Forest T.   +14 more
europepmc   +1 more source

FUSEObservation of the Narrow‐Line Seyfert 1 Galaxy RE 1034+39: Dependence of Broad Emission Line Strengths on the Shape of the Photoionizing Spectrum [PDF]

, 2006
D. Casebeer, Karen M. Leighly, E. Baron
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The oncogenic microRNA miR-222 promotes human LINE-1 retrotransposition. [PDF]

RNA Biol
Friehmann T, Abu Mohsen Y, Schlesinger Y, Ghantous L, Gamaev L, Landau Zenilman C, Harazi A, Galun E, Goldenberg DS.   +8 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

LINE-1, the NORth star of nucleolar organization. [PDF]

Genes Dev
Matsuo M, Cristofari G.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source