Results 261 to 270 of about 4,813,932 (329)

Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons. [PDF]

Clin Cancer Res
Michel M, Heidary M, Mechri A, Da Silva K, Gorse M, Dixon V, von Grafenstein K, Bianchi C, Hego C, Rampanou A, Lamy C, Kamal M, Le Tourneau C, Séné M, Bièche I, Reyes C, Gentien D, Stern MH, Lantz O, Cabel L, Pierga JY, Bidard FC, Azencott CA, Proudhon C.   +23 more
europepmc   +1 more source

Inhibitory Effect of (-)-Epigallocatechin and (-)-Epigallocatechin Gallate against Heregulin .BETA.1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell Line

, 2009
Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Yasuyuki Kawaratani, Tatsuya Shirahama, Minoru Sakaguchi, Kimiye Baba, Yukihiko Hara, Shinichi Uesato   +8 more
openalex   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions. [PDF]

Mob DNA
Nielsen MI, Wolters JC, Bringas OGR, Jiang H, Di Stefano LH, Oghbaie M, Hozeifi S, Nitert MJ, van Pijkeren A, Smit M, Ter Morsche L, Mourtzinos A, Deshpande V, Taylor MS, Chait BT, LaCava J.   +15 more
europepmc   +1 more source

A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line

, 2017
Dawn P. Wooley, Priyanka Sharma, John R. Weinstein, Poornima Kotha Lakshmi Narayan, David V. Schaffer, Katherine J. D. A. Excoffon   +5 more
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis. [PDF]

Sci Adv
Zernia S, Ettefa F, Sil S, Koeman C, Deplazes-Lauber J, Freitag M, Holt LJ, Stigler J.   +7 more
europepmc   +1 more source

Insights into the DNA cleavage mechanism of human LINE‐1 retrotransposon endonuclease

, 2008
Konstantinos Repanas, Gloria Fuentes, Serge X. Cohen, Alexandre M. J. J. Bonvin, Anastassis Perrakis   +4 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Impact of prematurity on LINE-1 promoter methylation. [PDF]

Epigenomics
Dos Santos PVBE, Brasil AA, Milone LTV, Chalfun G, Saide SCAO, Salú MDS, de Oliveira MBG, Robaina JR, Lima-Setta F, Rodrigues-Santos G, de Magalhães-Barbosa MC, da Cunha AJLA, Prata-Barbosa A.   +12 more
europepmc   +1 more source