Results 271 to 280 of about 28,196,398 (315)
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LINE-1 Retrotransposition in the Nervous System
Annual Review of Cell and Developmental Biology, 2012Long interspersed element-1 (LINE-1 or L1) is a repetitive DNA retrotransposon capable of duplication by a copy-and-paste genetic mechanism. Scattered throughout mammalian genomes, L1 is typically quiescent in most somatic cell types. In developing neurons, however, L1 can express and retrotranspose at high frequency.
Charles A, Thomas +2 more
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LINE-1: a human transposable element
Gene, 1993Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin.
M F, Singer +4 more
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Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein
Gene, 1993Nucleotide sequences near the 5' ends of some long interspersed elements-1 (LINE-1) from Homo sapiens (L1Hs) are undermethylated in cell lines which produce a L1Hs-encoded protein. In contrast, these sequences are methylated in cell lines with little or no detectable L1Hs expression.
R E, Thayer, M F, Singer, T G, Fanning
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Chromosoma, 2004
Long interspersed nuclear elements (LINEs) comprise about 21% of the human genome (of which L1 is most abundant) and are preferentially accumulated in AT-rich regions, as well as the X and Y chromosomes. Most knowledge of L1 distribution in mammals is restricted to human and mouse.
Paul D, Waters +3 more
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Long interspersed nuclear elements (LINEs) comprise about 21% of the human genome (of which L1 is most abundant) and are preferentially accumulated in AT-rich regions, as well as the X and Y chromosomes. Most knowledge of L1 distribution in mammals is restricted to human and mouse.
Paul D, Waters +3 more
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The Leading Edge, 1996
Mystery line 1 (TLE, February 1996) generated several interesting responses, three of which are printed below. (Editor’s note: Authors of published responses will receive a $20 voucher that may be applied to the purchase of any SEG book.)
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Mystery line 1 (TLE, February 1996) generated several interesting responses, three of which are printed below. (Editor’s note: Authors of published responses will receive a $20 voucher that may be applied to the purchase of any SEG book.)
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THE JUBILEE LINE. 1. THE PROJECT.
Proceedings of the Institution of Civil Engineers, 1979The article describes the purpose and layout of London's Jubilee Line underground railway and includes details of the design and construction of surface works. These include a new train servicing depot for the Bakerloo Line made necessary by the use of existing facilities by Jubilee Line rolling stock.
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Analysis of Somatic LINE-1 Insertions in Neurons
2017The method described here is designed to detect and localize somatic genome variation caused by the human retrotransposon LINE-1 (L1) in the genome of neuronal cells. This method combines single-cell manipulation and whole genome amplification technology with a hybridization-based, high-throughput sequencing method called Retrotransposon Capture ...
Sanchez-Luque, Francisco J. +2 more
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Expression Of Line-1 In Human Somatic Tissues And The Factors Correlated With Line- 1 Expression
2018Despite the long-held assumption that transposons are normally only expressed in the germline, recently we discovered that full length or partial transcripts of LINE1 are frequently found in the somatic cells. However, the extent of variation in LINE1 levels across different tissues and different individuals, and the genes and pathways that are co ...
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LINE-1: A mammalian transposable element
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1987T G, Fanning, M F, Singer
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An approximate line attractor in the hypothalamus encodes an aggressive state
Cell, 2023Aditya Nair +2 more
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