Results 261 to 270 of about 28,196,398 (315)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death. [PDF]

PLoS Genet
Korada S, Tam OH, Greco HC, Hammell MG, Dubnau J, Sher RB.   +5 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis. [PDF]

Sci Adv
Zernia S, Ettefa F, Sil S, Koeman C, Deplazes-Lauber J, Freitag M, Holt LJ, Stigler J.   +7 more
europepmc   +1 more source

LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancer Discov
You E, Patel BK, Rojas AS, Sun S, Danaher P, Ho NI, Phillips IE, Raabe MJ, Song Y, Xu KH, Kocher JR, Richieri PM, Shin P, Taylor MS, Nieman LT, Greenbaum BD, Ting DT.   +16 more
europepmc   +1 more source

Beyond <i>Trypanosoma cruzi</i>: LINE-1 Activation as a Driver of Chronic Inflammation in Chagas Disease. [PDF]

Int J Mol Sci
Dias M, Moraes A, Shiroma T, Pessoa V, Ermoges A, Vital T, Hagström L, de Sousa D, de Castro M, Dallago B, Bastos IMD, Nitz N, Hecht M.   +12 more
europepmc   +1 more source

LINE-1 cfDNA Methylation as an Emerging Biomarker in Solid Cancers. [PDF]

Cancers (Basel)
Gezer U, Özgür E, Yörüker EE, Polatoglou E, Holdenrieder S, Bronkhorst A.   +5 more
europepmc   +1 more source

Edge of RNA m6A modification on LINE-1 retrotransposons in central nervous system: merely a transcriptional control? [PDF]

Epigenomics
Sharma A, Dakal TC, Schmidt-Wolf IGH, Maciaczyk J, Steponaitis G.   +4 more
europepmc   +1 more source

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DA, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Gale-Hammell M, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

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Targeted cloning of a subfamily of LINE-1 elements by subfamily-specific LINE-1-PCR

Mammalian Genome, 1993
Subfamily-specific LINE-1 PCR (SSL1-PCR) is the targeted amplification and cloning of defined subfamilies of LINE-1 elements and their flanking sequences. The targeting is accomplished by incorporating a subfamily-specific sequence difference at the 3' end of a LINE-1 PCR primer and pairing it with a primer to an anchor ligated within the flanking ...
N C, Casavant, S C, Hardies
openaire   +2 more sources