Results 271 to 280 of about 4,881,979 (331)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis. [PDF]

Sci Adv
Zernia S, Ettefa F, Sil S, Koeman C, Deplazes-Lauber J, Freitag M, Holt LJ, Stigler J.   +7 more
europepmc   +1 more source

Scatter plot with 1:1 line and best fit line of the LSTM model prediction during model training (a) and evaluation (b) period.

Kamal Islam (7836617), Joseph A. Daraio (21156161), Mumtaz Cheema (10127028), Gabriela Sabau (21156164), Lakshman Galagedara (10127025)   +4 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Impact of prematurity on LINE-1 promoter methylation. [PDF]

Epigenomics
Dos Santos PVBE, Brasil AA, Milone LTV, Chalfun G, Saide SCAO, Salú MDS, de Oliveira MBG, Robaina JR, Lima-Setta F, Rodrigues-Santos G, de Magalhães-Barbosa MC, da Cunha AJLA, Prata-Barbosa A.   +12 more
europepmc   +1 more source

Predictors of T2D Remission (n = 1897). Footnote: The forest plot displays adjusted odds ratios (AORs) with 95% confidence intervals (CI) for various parameters to identify predictors. Each circle represents the point estimate, and the horizontal lines show the 95% confidence intervals, which reflect the range within which the true AOR falls. The dashed vertical line at AOR = 1 represents the line of no effect for predictors post-intervention.

Pramod Tripathi (18501225), Nidhi Kadam (18501228), Thejas Kathrikolly (13931158), Diptika Tiwari (6727811), Anagha Vyawahare (18501231), Baby Sharma (18501234), Malhar Ganla (18933704), Banshi Saboo (309669)   +7 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Process transfer of a-Si_xC_1-x passivation layers from a laboratorytype to an industrial in-line PECVD reactor

, 2008
Dominik Suwito, S. Janz, C. Schetter, Stefan W. Glunz, K. Roth   +4 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancer Discov
You E, Patel BK, Rojas AS, Sun S, Danaher P, Ho NI, Phillips IE, Raabe MJ, Song Y, Xu KH, Kocher JR, Richieri PM, Shin P, Taylor MS, Nieman LT, Greenbaum BD, Ting DT.   +16 more
europepmc   +1 more source