Results 31 to 40 of about 4,881,979 (331)

Engineered LINE-1 retrotransposition in nondividing human neurons [PDF]

, 2016
Half the human genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and containing an average
Amador-Cubero, Suyapa, Ayllon, Veronica, Benkaddour-Boumzaouad, Meriem, Blanco-Jimenez, Eva, Garcia-Castro, Javier, Garcia-Perez, Jose L., Goodier, John L., Heras, Sara R., Macia, Angela, Menendez, Pablo, Muotri, Alysson R., Muñoz-Lopez, Martin, Ng, Philip, Rubio, Alejandro, Sanchez, Laura, Widmann, Thomas J.   +15 more
core   +5 more sources

LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality

Epigenetics, 2017
Aberrant DNA methylation seems to be associated with prostate cancer behavior. We investigated LINE-1 methylation in prostate cancer and non-neoplastic tissue adjacent to tumor (NTAT) in association with mortality from prostate cancer.
Valentina Fiano, Daniela Zugna, Chiara Grasso, Morena Trevisan, Luisa Delsedime, Luca Molinaro, Anna Gillio-Tos, Franco Merletti, Lorenzo Richiardi   +8 more
doaj   +1 more source

Impact of Atrial Fibrillation Type on Outcomes of Transcatheter Aortic Valve Replacement for Aortic Stenosis: A Single-Center Analysis [PDF]

Texas Heart Institute Journal
Background: Atrial fibrillation (AF) is a recognized risk factor for mortality after transcatheter aortic valve replacement for severe aortic stenosis, but the impact of different types of AF on clinical outcomes remains unclear.
Yoshiyuki Yamashita, MD, PhD, Serge Sicouri, MD, Massimo Baudo, MD, Roberto Rodriguez, MD, Eric M. Gnall, DO, Paul M. Coady, MD, Harish Jarrett, MD, Sandra V. Abramson, MD, Katie M. Hawthorne, MD, Scott M. Goldman, MD, William A. Gray, MD, Basel Ramlawi, MD   +11 more
doaj   +1 more source

Approaches to Assessing the Strategic Sustainability of High-Risk Offshore Oil and Gas Projects

Journal of Marine Science and Engineering, 2020
In the face of today’s global challenges, oil and gas companies must define long-term priorities and opportunities in implementing complex Arctic offshore projects, taking into account environmental, economic, technological and social aspects.
Alexey Cherepovitsyn, Anna Tsvetkova, Nadejda Komendantova   +2 more
doaj   +1 more source

Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer

Epigenetics, 2017
Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements.
Natasha Vafadar-Isfahani, Christina Parr, Lara E. McMillan, Juliane Sanner, Zhao Yeo, Stephen Saddington, Oliver Peacock, Hazel A. Cruickshanks, Richard R. Meehan, Jonathan N. Lund, Cristina Tufarelli   +10 more
doaj   +1 more source

Epigenomic Diversity of Colorectal Cancer Indicated by LINE-1 Methylation in a Database of 869 Tumors [PDF]

, 2012
Background: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with global DNA methylation status ...
Baba, Yoshifumi, Fuchs, Charles Stewart, Giovannucci, Edward L., Hazra, Aditi, Hunter, David J., Huttenhower, Curtis, Nosho, Katsuhiko, Ogino, Shuji, Schernhammer, Eva S, Shima, Kaori, Tanaka, Noriko   +10 more
core   +1 more source

DNA methylation and socioeconomic status in a Mexican-American birth cohort. [PDF]

, 2018
Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships.
Coker, Eric, Eskenazi, Brenda, Gunier, Robert, HOLLAND, Nina, Huen, Karen   +4 more
core   +1 more source

Improvement of slope soil consolidation capacity of plant root system based on regulation of root architecture

Rock and Soil Mechanics, 2021
The effect of plant slope protection is strongly associated with the root architecture in soil. In this paper, the water?fertilizer combination method was used to regulate the plant root configuration, and the influence of the regulated plant root ...
LI Zhen-yu, OUYANG Miao, XIAO Hong-bin, WANG Ju-shan, LI Tao, LIU Si-si   +5 more
doaj   +1 more source

LINE-1 and Alu retrotransposition exhibit clonal variation [PDF]

, 2013
BACKGROUND: The non-long terminal repeat (non-LTR) retrotransposons, long interspersed element-1 (LINE-1) and Alu are currently active retroelements in humans.
Prescott L Deininger, Vincent A Streva, Zachary J Faber   +2 more
core   +1 more source

Well Killing Technology before Workover Operation in Complicated Conditions

Energies, 2021
Well killing is an important technological stage before conducting workover operation, one of the tasks of which is to preserve and restore the natural filtration characteristics of the bottomhole formation zone (BFZ). Special attention should be paid to
Dmitry V. Mardashov, Mikhail K. Rogachev, Yury V. Zeigman, Vyacheslav V. Mukhametshin   +3 more
doaj   +1 more source