Results 111 to 120 of about 24,592 (262)

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Multimodal Super‐Resolution Imaging of Nitrogen‐Vacancy Centers via High‐Index‐Induced Structured Illumination Microscopy and Optically Detected Magnetic Resonance Spectrometry

Advanced Science, EarlyView.
This work demonstrates a multimodal super‐resolution imaging technique for nitrogen‐vacancy centers by integrating high‐index‐induced structured illumination with optically detected magnetic resonance. By utilizing diamond's high refractive index, the method achieves sub‐100‐nm spatial resolution and enhanced localization. This dual‐modulation strategy
Kyu Ri Choi, Mohammed Zia Jalaludeen, Samuel Begumya, Yan Qiu Du, Dong Hee Park, Bin Chan Joo, Jae Hwan Yoo, Síle Nic Chormaic, Shilong Li, Yeon Ui Lee   +9 more
wiley   +1 more source

Non-Invasive Diagnosis of Angioma Serpiginosum Plantaris: High-Resolution Dermoscopy, High-Frequency Ultrasound, and Line-Field Confocal Optical Coherence Tomography

Journal of Vascular Diseases
We present a comprehensive study of acral serpiginous hemangioma, a rare vascular pathology. This distinctive manifestation was examined for the first time using high-resolution video dermoscopy (HRVD), high-frequency ultrasound (HFUS), and line-field ...
Linda Tognetti, Francesca La Marca, Elisa Cinotti, Pietro Rubegni   +3 more
doaj   +1 more source

Epidermal renewal during the treatment of atopic dermatitis lesions: A study coupling line‐field confocal optical coherence tomography with artificial intelligence quantifications

Skin research and technology
This study explores the application of Line‐field Confocal Optical Coherence Tomography (LC‐OCT) imaging coupled with artificial intelligence (AI)‐based algorithms to investigate atopic dermatitis (AD), a common inflammatory dermatosis.
H. Le Blay, E. Raynaud, Sonia Bouayadi, Elodie Rieux, Géraldine Rolland, A. Saussine, M. Jachiet, Jean-David Bouaziz, B. Lynch   +8 more
semanticscholar   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Advanced Science, EarlyView.
We developed a senolytic approach using procyanidin C1 (PCC1)‐loaded platform, a clinically established and safe hyaluronic acid‐based scaffold, to selectively eliminate senescent endothelial and microglial cells. This dual‐targeting strategy significantly suppresses pathological neovascularization and promotes vascular repair, presenting a safe and ...
Yali Zhou, Tianxing Chen, Peiyu Liu, Kangjia Lv, Yifan Wang, Xiaoqian Wang, Junwei Fang, Chong Chen, Zhaoyang Wang, Fang Wei, Xun Xu   +10 more
wiley   +1 more source

Assessment of atopic dermatitis in all phototypes using line‐field confocal optical coherence tomography (LC‐OCT) and reflectance confocal microscopy (RCM)

JEADV Clinical Practice
Background Theclinical presentation of atopic dermatitis (AD) varies in different skin phototypes and has been evaluated previously using reflectance confocal microscopy (RCM).
Samantha Ouellette, Thu Minh Truong, Samavia Khan, Sara Ragi, Shazli Razi, Babar Rao   +5 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM

Advanced Science, EarlyView.
Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An, Xuhong Guo, Zhongxia Cai, Yunze Lei, Kai Wen, Hongfei Suo, Xiaoyu Kong, Gerd Ulrich Nienhaus, Peng Gao   +8 more
wiley   +1 more source