Results 71 to 80 of about 10,691,328 (287)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Disentangling contributions of point and line defects in the Raman spectra of graphene-related materials

, 2017
The transition from graphene to a fully disordered sp2 carbon material can be idealized by either cutting graphene into smaller and smaller pieces, or adding more and more point defects.
Luiz Gustavo Cançado, Mateus Felipe Gomes da Silva, E. H. Martins-Ferreira, F. Hof, Katerina Kampioti, Kai Huang, A. Pénicaud, Carlos Alberto Achete, R. Capaz, A. Jorio   +9 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Line Defect Quantum Numbers & Anomalies

, 2022
We explore the connection between the global symmetry quantum numbers of line defects and 't Hooft anomalies. Relative to local (point) operators, line defects may transform projectively under both internal and spacetime symmetries. This phenomenon is known as symmetry fractionalization, and in general it signals the presence of certain discrete 't ...
Brennan, T. Daniel, Cordova, Clay, Dumitrescu, Thomas T.   +2 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

DEFECTS TRACKING AND RESEARCH [PDF]

NCBDDD is committed to helping individuals with congenital heart defects in each phase of life, through public health tracking, research, prevention, and intervention.CS321756-APublication date from document properties.CHD-flyer-improving-health-lifespan.

core  

Graphene Valley Filter Using a Line Defect

Physical Review Letters, 2011
With its two degenerate valleys at the Fermi level, the band structure of graphene provides the opportunity to develop unconventional electronic applications. Herein, we show that electron and hole quasiparticles in graphene can be filtered according to which valley they occupy without the need to introduce confinement.
Gunlycke, Daniel, White, Carter T.
openaire   +4 more sources

OPE of line defects in 5d En SCFT

Journal of High Energy Physics, 2022
Abstract 5d ray index is the 5d superconformal index in the presence of a ray-like defect. An elementary ray defect flows to a fundamental Wilson ray in IR gauge theory. In 5d $$ \mathcal{N} $$ N = 1 superconformal field theory(SCFT) with En global symmetry, we compute the ray index associated ...
openaire   +3 more sources