Results 121 to 130 of about 8,892,596 (302)

Modelling Helmet Manufacturing System Using Discrete Event Simulation

Engineering Proceedings
We simulated the manufacturing production line in a micro, small, and medium enterprise (MSME) to assess the efficiency of a helmet product organization, using ARENA simulation modelling software version 15.10.00000.
Khoong Tai Wai, Wan Laailatul Hanim Mat Desa, Lim Li Li, Houng Chien Tan, Chan Ling Meng, Kumara Adji Kusuma   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ICT PENETRATION AND AGGREGATE PRODUCTION EFFICIENCY: EMPIRICAL EVIDENCE FOR A CROSS-SECTION OF FIFTY COUNTRIES [PDF]

This study investigates the impact of telecommunications penetration on the aggregate production efficiency in a large cross-section of fifty countries.
Alexandre Repkine
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Heuristics comparison for u-shaped assembly line balancing in the apparel factory

KKU Engineering Journal, 2014
In recent year, many industries have adopted a Just-in-time (JIT) approach to manufacturing. One of the important changes resulting from JIT implementation is the replacement of the traditional straight lines with Ushaped assembly lines.
Nuchsara Kriengkorakot, Preecha Kriengkorakot   +1 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Solution approach using heuristic and artificial neural networks methods in assembly line balancing problems: A case study in the lighting industry

Heliyon
Assembly line efficiency is one of the most important parameters that determine the overall efficiency of a manufacturing company. The production of a product under optimum conditions is ensured by a balanced assembly.
Yelda Karatepe Mumcu
doaj   +1 more source

Efficiency Analysis of an Automatic Production Line [PDF]

This paper presents an efficiency analysis of yogurt production line. The goal is to describe a real production line and based on this description, create a digital twin in Tecnomatix Plant Simulation, which will be used to analyze efficiency and ...
Bortlík, Dominik, Kaczmarczyk, Václav
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Energy Efficiency Board 2019 programs and operations report.

, 2020
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
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