Results 181 to 190 of about 8,892,596 (302)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Enhanced Line Search Improves Robustness and Efficiency of Pose Sampling in Protein-Ligand Docking. [PDF]

J Chem Theory Comput
Gaskin L, Welsch M, Kirchmair J, Kimiaei M.   +3 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Unveiling a Near-Total Rear Passivation for High Performance of Ultra-Thin ACIGS. [PDF]

Adv Sci (Weinh)
Pinheiro XL, Oliveira AJN, Violas AF, Oliveira K, Fernandes PA, Edoff M, Salomé PMP, Teixeira JP.   +7 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Performance enhancement of 6g millimeter wave links via RIS beamforming and CDL-based channel modeling. [PDF]

PLoS One
Swamy K, Turpati S, Medasani S, Addepalli T, Chandra BR, Sharma M, Pathan S.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

FDTD Analysis of End-Fire Coupling Between Mid-IR On-Chip Light Sources on Si and As₂Se₃-on-CaF₂ Waveguide from 3 to 8 µm for Spectroscopic Sensing. [PDF]

Sensors (Basel)
Srikam S, Limsuwan P, Chaisakul P.
europepmc   +1 more source

Automatic production line efficiency evaluation and optimization

The article deals with the analysis of the production line in terms of overall efficiency. The aim is to define the areas that play a role in overall efficiency and then devise appropriate solutions to improve them.
Kaczmarczyk, Václav, Štěrba, Zdeněk
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