Results 131 to 140 of about 1,844,339 (310)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

open access: yesMolecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban   +12 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

On Wiener index of graphs and their line graphs

open access: yes, 2009
The Wiener index of a graph G, denoted by W(G), is the sum of distances between all pairs of vertices in G. In this paper, we consider the relation between the Wiener index of a graph, G, and its line graph, L(G). We show that if G is of minimum degree at least two, then W(G) <= W(L(G)). We prove that for every non-negative integer g_0, there exists
Cohen, Nathann   +4 more
openaire   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

open access: yesFEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu   +9 more
wiley   +1 more source

Homomorphic Preimages of Geometric Cycles

open access: yes, 2015
A graph G is a homomorphic preimage of another graph H, or equivalently G is H-colorable, if there exists a graph homomorphism from G to H. A classic problem is to characterize the family of homomorphic preimages of a given graph H.
Cockburn, Sally
core  

Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis

open access: yesFEBS Open Bio, EarlyView.
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir   +4 more
wiley   +1 more source

The line completion number of hypercubes

open access: yesAKCE International Journal of Graphs and Combinatorics, 2019
In 1992, Bagga, Beineke, and Varma introduced the concept of the super line graph of index r of a graph G, denoted by ℒr(G). The vertices of ℒr(G)are the r-subsets of E(G), and two vertices S and T are adjacent if there exist s∈S and t∈T such that s and ...
S.A. Tapadia, B.N. Waphare
doaj  

A survey of line digraphs and generalizations [PDF]

open access: yesDiscrete Mathematics Letters, 2021
Jay S. Bagga, Lowell W. Beineke
doaj   +1 more source

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