Results 131 to 140 of about 5,414,210 (302)
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Height-Preserving Transformations of Planar Graph Drawings
, 2014 There are numerous styles of planar graph drawings, such as straight-line drawings, poly-line drawings, orthogonal graph drawings and visibility representations. Given a planar drawing in one of these styles, can it be converted it to another style while
Biedl, Therese, Therese Biedl
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Every 6-connected line graph is hamiltonian [PDF]
, 2005 Thomassen [J. Graph Theory, 10 (1986) 309-324] conjectured that every 4-connected line graph is hamiltonian. Zhan in [Discrete Math., 89 (1991) 89-95] proved that every 7-connected line graph is hamiltonian connected. In this paper, we prove that every 3-
Lai, Hongjian
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Irregularity indices for line graph of Dutch windmill graph
, 2020 Among topological descriptors topological indices are significant and they have a conspicuous role in chemistry. Dutch Windmill graph Dxy can be obtain by taking x copies of cycle Cy with a vertex in common.
AL-Mayyahi, Suad Younus A. AL-Mayyahi +3 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
On the critical lines of a graph [PDF]
Pacific Journal of Mathematics, 1967 Beineke, Lowell W. +2 more
openaire +2 more sources