Results 161 to 170 of about 5,172,585 (353)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Height-Preserving Transformations of Planar Graph Drawings
, 2014 There are numerous styles of planar graph drawings, such as straight-line drawings, poly-line drawings, orthogonal graph drawings and visibility representations. Given a planar drawing in one of these styles, can it be converted it to another style while
Biedl, Therese, Therese Biedl
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Plithogenic Line Graph, Star Graph, and Regular Graph [PDF]
Graph theory, a branch of mathematics, studies relationships between entities using vertices and edges. In this field, Uncertain Graph Theory has emerged to capture the uncertainties inherent in real-world networks.
Fujita, Takaaki
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
On the critical lines of a graph [PDF]
Pacific Journal of Mathematics, 1967 Beineke, Lowell W. +2 more
openaire +2 more sources
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
The Behavior of Tree-Width and Path-Width Under Graph Operations and Graph Transformations
Tree-width and path-width are well-known graph parameters. Many NP-hard graph problems admit polynomial-time solutions when restricted to graphs of bounded tree-width or bounded path-width. In this work, we study the behavior of tree-width and path-width
Frank Gurski, Robin Weishaupt
core +1 more source
Multilayer Drawings of Clustered Graphs
, 2014 The cluster adjacency graph of a flat clustered graph C(G, T ) is the graph A whose vertices are the clusters in T and whose edges connect clusters containing vertices that are adjacent in G.
Fabrizio Frati, FRATI, FABRIZIO
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source