Results 61 to 70 of about 167,358 (260)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Benchmarking Vectorized Building Footprint Extraction from Very High Resolution Aerial Imagery [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesAccurate, topologically consistent building footprints are essential for building reconstruction and GIS applications. But high-resolution orthophotos often contain occlusions (trees, cast shadows, etc.) or dense roof structures that challenge pixel ...
M. Büyükdemircioğlu +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Innovative segmentation technique for aerial power lines via amplitude stretching transform
Scientific ReportsAccurate segmentation of power line targets helps quickly locate faults, evaluate line conditions, and provides key image data support and analysis for the safe and stable operation of the power system.The aerial power line in segmentation due to the ...
Pengfei Xu +3 more
doaj +1 more source
Topics on line segments and polygons
Discrete Mathematics, 1996 For finite sets of pairwise disjoint line segments in the plane, figures such as simple polygons, simple paths, or trees are considered, where the condition is that the figure may only use the endpoints of the line segments and may not intersect any line segment properly.
Kiyoshi Hosono +2 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
EURASIP Journal on Advances in Signal Processing, 2005 A new method for the multiband segmentation of a spectroscopic line data cube is presented. This method is intended to help astronomers to handle complex spectroscopic line data cubes where the inspection of the channel and moment maps is difficult. Due
Vollmer Bernd +3 more
doaj +1 more source
The Multiscale Line Segment Detector [PDF]
, 2017 We propose a multiscale extension of a well-known line segment detector, LSD. We show that its multiscale nature makes it much less susceptible to over-segmentation and more robust to low contrast and less sensitive to noise, while keeping the parameter-less advantage of LSD and still being fast.
Salaün, Yohann +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source